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GPCR

NameMuscarinic acetylcholine receptor M4
SpeciesRattus norvegicus (Rat)
GeneChrm4
Synonymcholinergic receptor
cholinergic receptor, muscarinic 4
Chrm-4
HM3
M4 receptor
DiseaseN/A for non-human GPCRs
Length478
Amino acid sequenceMXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProtP08485
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL317
IUPHAR16
DrugBankN/A

Ligand

Name633283-39-3
Molecular formulaC17H16ClN3OS
IUPAC name3-amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Molecular weight345.845
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.6
Synonyms3-amino-N-(4-chlorobenzyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
B7285
f-LIGRLO-NH2
RT-016241
VU10010
[ Show all ]
Inchi KeyFPRULFHDSFKYBV-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H16ClN3OS/c1-9-7-10(2)21-17-13(9)14(19)15(23-17)16(22)20-8-11-3-5-12(18)6-4-11/h3-7H,8,19H2,1-2H3,(H,20,22)
PubChem CID714286
ChEMBLCHEMBL1212994
IUPHARN/A
BindingDB50323691
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity36.9 %PMID18059262ChEMBL
Activity42.7 %PMID18059262ChEMBL
Activity43.0 %PMID18059262ChEMBL
Activity60.5 %PMID18059262ChEMBL
Activity98.5 %PMID18059262ChEMBL
Activity107.9 %PMID18059262ChEMBL
EC500.000339 nMN/ABindingDB
EC50400.0 nMPMID18059262BindingDB,ChEMBL
FC14.0 -PMID18059262ChEMBL
FC47.0 -PMID18059262ChEMBL
Inhibition10.9 %PMID18059262ChEMBL
Inhibition16.1 %PMID18059262ChEMBL
Inhibition61.7 %PMID18059262ChEMBL
Inhibition62.2 %PMID18059262ChEMBL

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