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GPCR

NameMuscarinic acetylcholine receptor M1
SpeciesRattus norvegicus (Rat)
GeneChrm1
Synonymcholinergic receptor, muscarinic 1
cholinergic receptor, muscarinic 1, CNS
cholinergic receptor
M1 muscarinic acetylcholine receptor
M1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProtP08482
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL276
IUPHAR13
DrugBankN/A

Ligand

NameCHEMBL126735
Molecular formulaC23H30N2
IUPAC nameN-benzhydryl-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)ethanamine
Molecular weight334.507
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.7
SynonymsBenzhydryl-[2-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-ethyl]-amine
N-benzhydryl-2-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)ethanamine
AC1L8IGX
NCI60_039930
BDBM50106312
Inchi KeyALPHRFUELPDGHE-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H30N2/c1-25-21-12-13-22(25)17-18(16-21)14-15-24-23(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-11,18,21-24H,12-17H2,1H3
PubChem CID401890
ChEMBLCHEMBL126735
IUPHARN/A
BindingDB50106312
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki340.0 nMPMID11689080BindingDB,ChEMBL

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