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GPCR

NameMetabotropic glutamate receptor 6
SpeciesHomo sapiens (Human)
GeneGRM6
Synonymnob3
nob2
nerg1
mGluR6
mGlu6 receptor
[ Show all ]
DiseaseN/A
Length877
Amino acid sequenceMARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
UniProtO15303
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4573
IUPHAR294
DrugBankN/A

Ligand

Name(2S,3S)-3-(carboxymethyl)azetidine-2-carboxylic acid
Molecular formulaC6H9NO4
IUPAC name(2S,3S)-3-(carboxymethyl)azetidine-2-carboxylic acid
Molecular weight159.141
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP-3.3
SynonymsJ-011895
AKOS022180391
ZINC4262470
185387-36-4
CHEMBL314690
[ Show all ]
Inchi KeyFQUPICCTRPWMDZ-UCORVYFPSA-N
Inchi IDInChI=1S/C6H9NO4/c8-4(9)1-3-2-7-5(3)6(10)11/h3,5,7H,1-2H2,(H,8,9)(H,10,11)/t3-,5-/m0/s1
PubChem CID2733519
ChEMBLCHEMBL314690
IUPHARN/A
BindingDB50288204
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<300000.0 nM, Bioorg. Med. Chem. Lett., (1996) 6:21:2559BindingDB,ChEMBL
Inhibition0.0 %Bioorg. Med. Chem. Lett., (1996) 6:21:2559ChEMBL
Max response17.0 %Bioorg. Med. Chem. Lett., (1996) 6:21:2559ChEMBL

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