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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL121960
Molecular formula	C30H38N4O3S
IUPAC name	(E)-5-amino-N-[(2R)-3-(1-benzothiophen-3-yl)-1-[methyl-[(2R)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]-N,5-dimethylhex-2-enamide
Molecular weight	534.719
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.0
Synonyms	BDBM50066809 N-(5-Amino-5-methyl-2-hexenoyl)-N-methyl-3-(1-benzothiophene-3-yl)-D-Ala-N-methyl-D-Phe-NHMe SCHEMBL6319014 (E)-5-Amino-5-methyl-hex-2-enoic acid {(R)-2-benzo[b]thiophen-3-yl-1-[methyl-((R)-1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-ethyl}-methyl-amide
Inchi Key	FQVNNPJLRDCWIO-VUDVURFASA-N
Inchi ID	InChI=1S/C30H38N4O3S/c1-30(2,31)17-11-16-27(35)33(4)25(19-22-20-38-26-15-10-9-14-23(22)26)29(37)34(5)24(28(36)32-3)18-21-12-7-6-8-13-21/h6-16,20,24-25H,17-19,31H2,1-5H3,(H,32,36)/b16-11+/t24-,25-/m1/s1
PubChem CID	10721075
ChEMBL	CHEMBL121960
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	35.0 nM	PMID9733496	ChEMBL
Emax	80.0 %	PMID9733496	ChEMBL

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