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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL1086508
Molecular formulaC16H15Cl2F3N4O
IUPAC name1-(1-cyclopropylethyl)-5-[2,6-dichloro-4-(trifluoromethyl)anilino]-3-methyl-1,2,4-triazin-6-one
Molecular weight407.218
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.2
SynonymsBDBM50320231
1-(1-cyclopropylethyl)-5-(2,6-dichloro-4-(trifluoromethyl)phenylamino)-3-methyl-1,2,4-triazin-6(1H)-one
Inchi KeyALYLZBHAZKKANS-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H15Cl2F3N4O/c1-7(9-3-4-9)25-15(26)14(22-8(2)24-25)23-13-11(17)5-10(6-12(13)18)16(19,20)21/h5-7,9H,3-4H2,1-2H3,(H,22,23,24)
PubChem CID46891033
ChEMBLCHEMBL1086508
IUPHARN/A
BindingDB50320231
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5014.0 nMPMID20483614BindingDB,ChEMBL

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