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GPCR

NameCysteinyl leukotriene receptor 1
SpeciesCavia porcellus (Guinea pig)
GeneCYSLTR1
SynonymCysLTR1
Cysteinyl leukotriene D4 receptor
LTD4 receptor
DiseaseN/A for non-human GPCRs
Length340
Amino acid sequenceMDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
UniProtQ2NNR5
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5645
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL11820
Molecular formulaC26H18N2O3
IUPAC name4-hydroxy-3-[(E)-3-[3-(quinolin-2-ylmethoxy)phenyl]prop-2-enoyl]benzonitrile
Molecular weight406.441
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.4
SynonymsSCHEMBL6967958
Inchi KeyAMADQNVKJGRKSM-XYOKQWHBSA-N
Inchi IDInChI=1S/C26H18N2O3/c27-16-19-9-13-26(30)23(15-19)25(29)12-8-18-4-3-6-22(14-18)31-17-21-11-10-20-5-1-2-7-24(20)28-21/h1-15,30H,17H2/b12-8+
PubChem CID10763856
ChEMBLCHEMBL11820
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition38.0 %PMID9089329ChEMBL

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