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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Ligand

NameCHEMBL320991
Molecular formulaC20H30ClNO
IUPAC name4-(4-chlorophenyl)-1-(cyclooctylmethyl)piperidin-4-ol
Molecular weight335.916
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP5.5
Synonyms1-(Cyclooctylmethyl)-4-(4-chlorophenyl)piperidine-4-ol
BDBM50132648
4-(4-Chloro-phenyl)-1-cyclooctylmethyl-piperidin-4-ol
Inchi KeyAMDBWPUYNXJYJF-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H30ClNO/c21-19-10-8-18(9-11-19)20(23)12-14-22(15-13-20)16-17-6-4-2-1-3-5-7-17/h8-11,17,23H,1-7,12-16H2
PubChem CID44339504
ChEMBLCHEMBL320991
IUPHARN/A
BindingDB50132648
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki502.0 nMPMID12951102BindingDB
Ki502.0 nMPMID12951102ChEMBL

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