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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesMus musculus (Mouse)
GenePtger3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3
prostanoid EP3 receptor
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProtP30557
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4336
IUPHAR342
DrugBankN/A

Ligand

NameCHEMBL597786
Molecular formulaC28H29ClFNO4
IUPAC name3-[2-[[1-(3-chloro-4-fluorophenyl)-3-methylbutyl]carbamoyl]-4-(phenoxymethyl)phenyl]propanoic acid
Molecular weight497.991
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP6.4
SynonymsBDBM50307433
SCHEMBL2982996
3-[2-({[1-(3-Chloro-4-fluorophenyl)-3-methylbutyl]-amino}carbonyl)-4-(phenoxymethyl)phenyl]propanoic acid
Inchi KeyFWASKMZBRDMIFV-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H29ClFNO4/c1-18(2)14-26(21-10-12-25(30)24(29)16-21)31-28(34)23-15-19(8-9-20(23)11-13-27(32)33)17-35-22-6-4-3-5-7-22/h3-10,12,15-16,18,26H,11,13-14,17H2,1-2H3,(H,31,34)(H,32,33)
PubChem CID23017331
ChEMBLCHEMBL597786
IUPHARN/A
BindingDB50307433
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5025.0 nMPMID20129791BindingDB,ChEMBL
Ki0.26 nMPMID20129791BindingDB,ChEMBL

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