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Name | Melanin-concentrating hormone receptor 1 |
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Species | Homo sapiens (Human) |
Gene | MCHR1 |
Synonym | SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R [ Show all ] |
Disease | Obesity Obesity; Anxiety; Depression |
Length | 422 |
Amino acid sequence | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT |
UniProt | Q99705 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99705 |
3D structure model | This predicted structure model is from GPCR-EXP Q99705. |
BioLiP | N/A |
Therapeutic Target Database | T09572 |
ChEMBL | CHEMBL344 |
IUPHAR | 280 |
DrugBank | BE0003478 |
Name | CHEMBL194408 |
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Molecular formula | C23H26Cl2N4O2 |
IUPAC name | 2-(2,4-dichlorophenoxy)-N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methylquinolin-6-yl]acetamide |
Molecular weight | 461.387 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 5.2 |
Synonyms | BDBM50172432 SCHEMBL5910434 2-(2,4-Dichloro-phenoxy)-N-{2-[(2-dimethylamino-ethyl)-methyl-amino]-4-methyl-quinolin-6-yl}-acetamide |
Inchi Key | FWSBSBDRADXORX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H26Cl2N4O2/c1-15-11-22(29(4)10-9-28(2)3)27-20-7-6-17(13-18(15)20)26-23(30)14-31-21-8-5-16(24)12-19(21)25/h5-8,11-13H,9-10,14H2,1-4H3,(H,26,30) |
PubChem CID | 11512135 |
ChEMBL | CHEMBL194408 |
IUPHAR | N/A |
BindingDB | 50172432 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5.9 nM | PMID16134937 | BindingDB,ChEMBL |
IC50 | 9.4 nM | PMID16134937 | BindingDB,ChEMBL |
IC50 | 66.0 nM | PMID16134937 | BindingDB,ChEMBL |
Kb | 5.0 nM | PMID16134937 | ChEMBL |
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