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GPCR

NameD(2) dopamine receptor
SpeciesMus musculus (Mouse)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61168
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3427
IUPHAR215
DrugBankN/A

Ligand

NameCHEMBL543438
Molecular formulaC16H19ClF5NO
IUPAC name1-(cyclopropylmethyl)-4-[(2,3,4,5,6-pentafluorophenoxy)methyl]piperidine;hydrochloride
Molecular weight371.776
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogPNone
SynonymsN/A
Inchi KeyFWYDFWDNCYQWAB-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H18F5NO.ClH/c17-11-12(18)14(20)16(15(21)13(11)19)23-8-10-3-5-22(6-4-10)7-9-1-2-9;/h9-10H,1-8H2;1H
PubChem CID10339215
ChEMBLCHEMBL543438
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC505684.0 nMPMID1360026ChEMBL

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