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Name | Somatostatin receptor type 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Sstr1 |
Synonym | SRIF-2 SS-1-R SS1-R SS1R SST1 receptor |
Disease | N/A for non-human GPCRs |
Length | 391 |
Amino acid sequence | MFPNGTAPSPTSSPSSSPGGCGEGVCSRGPGSGAADGMEEPGRNSSQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCASRISTL |
UniProt | P28646 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4652 |
IUPHAR | 355 |
DrugBank | N/A |
Name | CHEMBL251116 |
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Molecular formula | C32H38N4O3 |
IUPAC name | [(3R,4aR,10aR)-6-methoxy-1-methyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-3-yl]-[4-(6-phenylmethoxypyridin-2-yl)piperazin-1-yl]methanone |
Molecular weight | 526.681 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 4.8 |
Synonyms | BDBM50423353 |
Inchi Key | FXCGZOIUXOVRMD-STROYTFGSA-N |
Inchi ID | InChI=1S/C32H38N4O3/c1-34-21-26(18-25-19-27-24(20-28(25)34)10-6-11-29(27)38-2)32(37)36-16-14-35(15-17-36)30-12-7-13-31(33-30)39-22-23-8-4-3-5-9-23/h3-13,25-26,28H,14-22H2,1-2H3/t25-,26-,28-/m1/s1 |
PubChem CID | 44441873 |
ChEMBL | CHEMBL251116 |
IUPHAR | N/A |
BindingDB | 50423353 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 104.71 nM | PMID17512199 | ChEMBL |
Kd | 105.0 nM | PMID17512199 | BindingDB |
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