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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL34224
Molecular formulaC14H19ClN2O3
IUPAC name(1-methylpiperidin-4-yl) 4-amino-5-chloro-2-methoxybenzoate
Molecular weight298.767
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.3
SynonymsAKOS010536375
4-Amino-5-chloro-2-methoxy-benzoic acid 1-methyl-piperidin-4-yl ester
BDBM50282689
Inchi KeyFXYDPARKRWHKDN-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H19ClN2O3/c1-17-5-3-9(4-6-17)20-14(18)10-7-11(15)12(16)8-13(10)19-2/h7-9H,3-6,16H2,1-2H3
PubChem CID44281492
ChEMBLCHEMBL34224
IUPHARN/A
BindingDB50282689
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki23.0 nM, Bioorg. Med. Chem. Lett., (1994) 4:12:1433BindingDB,ChEMBL

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