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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL160581 |
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Molecular formula | C26H28N4O2 |
IUPAC name | 2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]-1-(4-naphthalen-1-ylpiperazin-1-yl)ethanone |
Molecular weight | 428.536 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 3.7 |
Synonyms | BDBM50286670 L011209 2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-naphthalen-1-yl-piperazin-1-yl)-ethanone |
Inchi Key | FYCXANKHKYEXTR-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H28N4O2/c27-11-10-20-17-28-24-9-8-21(16-23(20)24)32-18-26(31)30-14-12-29(13-15-30)25-7-3-5-19-4-1-2-6-22(19)25/h1-9,16-17,28H,10-15,18,27H2 |
PubChem CID | 10048222 |
ChEMBL | CHEMBL160581 |
IUPHAR | N/A |
BindingDB | 50286670 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <1000.0 nM | , Bioorg. Med. Chem. Lett., (1995) 5:7:663 | BindingDB,ChEMBL |
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