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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL132655
Molecular formulaC27H26ClN3O
IUPAC name2-(3-chlorophenyl)-2-[4-(3,3-diphenylpropanoyl)piperazin-1-yl]acetonitrile
Molecular weight443.975
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.0
Synonyms(3-Chloro-phenyl)-[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-acetonitrile
BDBM50003547
2-[4-(3,3-Diphenylpropionyl)-1-piperazinyl]-2-(3-chlorophenyl)acetonitrile
Inchi KeyFYZXXCWVPPJHHN-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H26ClN3O/c28-24-13-7-12-23(18-24)26(20-29)30-14-16-31(17-15-30)27(32)19-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,18,25-26H,14-17,19H2
PubChem CID10026451
ChEMBLCHEMBL132655
IUPHARN/A
BindingDB50003547
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ID50<5.0 mg.kg-1PMID1433215ChEMBL

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