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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Substance-K receptor
Species	Cavia porcellus (Guinea pig)
Gene	TACR2
Synonym	Neurokinin A receptor NK-2 receptor NK-2R SKR Tachykinin receptor 2
Disease	N/A for non-human GPCRs
Length	402
Amino acid sequence	MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMAGDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS
UniProt	Q64077
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2647
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL354756
Molecular formula	C32H36Cl2N4O6
IUPAC name	1-[2-[(5R)-5-(3,4-dichlorophenyl)-3-(3,4,5-trimethoxybenzoyl)-1,3-oxazolidin-5-yl]ethyl]-4-pyridin-2-ylpiperidine-4-carboxamide
Molecular weight	643.562
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	3.8
Synonyms	1-[2-[(5R)-3-(3,4,5-Trimethoxybenzoyl)-5-(3,4-dichlorophenyl)-5alpha-oxazolidinyl]ethyl]-4-(2-pyridinyl)piperidine-4-carboxamide
Inchi Key	FZNIBWHYEFRVEA-YTTGMZPUSA-N
Inchi ID	InChI=1S/C32H36Cl2N4O6/c1-41-25-16-21(17-26(42-2)28(25)43-3)29(39)38-19-32(44-20-38,22-7-8-23(33)24(34)18-22)11-15-37-13-9-31(10-14-37,30(35)40)27-6-4-5-12-36-27/h4-8,12,16-18H,9-11,13-15,19-20H2,1-3H3,(H2,35,40)/t32-/m0/s1
PubChem CID	44382270
ChEMBL	CHEMBL354756
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	83.0 %	PMID10206553	ChEMBL

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