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GPCR

NameD(1A) dopamine receptor
SpeciesSus scrofa (Pig)
GeneDRD1
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtP50130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5067
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL405260
Molecular formulaC20H23FN4O
IUPAC name2-[[4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine
Molecular weight354.429
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP2.8
SynonymsBDBM50373490
Inchi KeyGACKYORUNWZVHC-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H23FN4O/c21-8-14-26-20-7-2-1-6-19(20)24-12-10-23(11-13-24)16-17-15-18-5-3-4-9-25(18)22-17/h1-7,9,15H,8,10-14,16H2
PubChem CID24824062
ChEMBLCHEMBL405260
IUPHARN/A
BindingDB50373490
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4800.0 nMPMID18307287BindingDB,ChEMBL

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