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GPCR

NameCannabinoid receptor 2
SpeciesRattus norvegicus (Rat)
GeneCnr2
SynonymPeripheral cannabinoid receptor
CB2-R
CB2 receptor
CB2
CB-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
UniProtQ9QZN9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2470
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL524826
Molecular formulaC19H20ClFN4O2
IUPAC name5-[3-(2-tert-butylpyrimidin-5-yl)oxypropyl]-3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazole
Molecular weight390.843
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP4.8
SynonymsBDBM50272429
2-tert-Butyl-5-(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)propoxy)pyrimidine
Inchi KeyGASFAQIEJVLYMT-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H20ClFN4O2/c1-19(2,3)18-22-10-13(11-23-18)26-8-4-5-16-24-17(25-27-16)14-7-6-12(21)9-15(14)20/h6-7,9-11H,4-5,8H2,1-3H3
PubChem CID25034273
ChEMBLCHEMBL524826
IUPHARN/A
BindingDB50272429
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5016.0 nMPMID18680277BindingDB,ChEMBL
Emax100.0 %PMID18680277ChEMBL

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