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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesHomo sapiens (Human)
GenePTGER3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
PGE2-R
prostaglandin E receptor 3
[ Show all ]
DiseasePain
Peripheral vascular disease
Asthma
Glaucoma
Length390
Amino acid sequenceMKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
UniProtP43115
Protein Data Bank6m9t
GPCR-HGmod modelP43115
3D structure modelThis structure is from PDB ID 6m9t.
BioLiPBL0434681
Therapeutic Target DatabaseT85467
ChEMBLCHEMBL3710
IUPHAR342
DrugBankBE0002375

Ligand

NameCHEMBL123844
Molecular formulaC27H22O3
IUPAC name2-[2-[3-(2-phenylmethoxyphenyl)phenyl]phenyl]acetic acid
Molecular weight394.47
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.3
Synonyms2''-(Benzyloxy)-1,1':3',1''-terbenzene-2-acetic acid
(2''''-Benzyloxy-[1,1'';3'',1'''']terphenyl-2-yl)-acetic acid
BDBM50134520
Inchi KeyAMSJJJTTZPVHKS-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H22O3/c28-27(29)18-23-11-4-5-14-24(23)21-12-8-13-22(17-21)25-15-6-7-16-26(25)30-19-20-9-2-1-3-10-20/h1-17H,18-19H2,(H,28,29)
PubChem CID44349531
ChEMBLCHEMBL123844
IUPHARN/A
BindingDB50134520
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki1700.0 nMPMID14552786BindingDB,ChEMBL

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