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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL214177
Molecular formulaC24H31N3O3
IUPAC name4-(3,4-dimethylphenoxy)-3-(propanoylamino)-N-(2-pyrrolidin-1-ylethyl)benzamide
Molecular weight409.53
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.6
SynonymsBDBM50192517
SCHEMBL6376595
4-(3,4-dimethylphenoxy)-3-propionamido-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
Inchi KeyGBYGZYDTFFMMED-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H31N3O3/c1-4-23(28)26-21-16-19(24(29)25-11-14-27-12-5-6-13-27)8-10-22(21)30-20-9-7-17(2)18(3)15-20/h7-10,15-16H,4-6,11-14H2,1-3H3,(H,25,29)(H,26,28)
PubChem CID11517116
ChEMBLCHEMBL214177
IUPHARN/A
BindingDB50192517
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1000.0 nMPMID16887348ChEMBL

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