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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH3
Synonym	H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
UniProt	Q9JI35
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5076
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1222420
Molecular formula	C17H26N4O
IUPAC name	(4-methylpiperazin-1-yl)-[1-(pyridin-4-ylmethyl)piperidin-4-yl]methanone
Molecular weight	302.422
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	0.5
Synonyms	(4-methylpiperazin-1-yl)(1-(pyridin-4-ylmethyl)piperidin-4-yl)methanone BDBM50325482
Inchi Key	AMXIWGVKXSBUBW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H26N4O/c1-19-10-12-21(13-11-19)17(22)16-4-8-20(9-5-16)14-15-2-6-18-7-3-15/h2-3,6-7,16H,4-5,8-14H2,1H3
PubChem CID	49864752
ChEMBL	CHEMBL1222420
IUPHAR	N/A
BindingDB	50325482
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	355.0 nM	PMID20685118	BindingDB,ChEMBL

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