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GPCR

NameD(1A) dopamine receptor
SpeciesSus scrofa (Pig)
GeneDRD1
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtP50130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5067
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL407818
Molecular formulaC18H20N4O
IUPAC name4-[4-(pyrazolo[1,5-a]pyridin-3-ylmethyl)piperazin-1-yl]phenol
Molecular weight308.385
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.1
SynonymsBDBM50373489
Inchi KeyGDEQPGACTRNZFK-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H20N4O/c23-17-6-4-16(5-7-17)21-11-9-20(10-12-21)14-15-13-19-22-8-2-1-3-18(15)22/h1-8,13,23H,9-12,14H2
PubChem CID24824066
ChEMBLCHEMBL407818
IUPHARN/A
BindingDB50373489
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki9900.0 nMPMID18307287BindingDB,ChEMBL

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