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Name | Alpha-1A adrenergic receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Adra1a |
Synonym | alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV |
UniProt | P43140 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL319 |
IUPHAR | 22 |
DrugBank | N/A |
Name | clomipramine |
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Molecular formula | C19H23ClN2 |
IUPAC name | 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine |
Molecular weight | 314.857 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 5.2 |
Synonyms | Spectrum5_001235 ZINC20248 Clomipramina 17321-77-6 (mono-hydrochloride) D07727 [ Show all ] |
Inchi Key | GDLIGKIOYRNHDA-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3 |
PubChem CID | 2801 |
ChEMBL | CHEMBL415 |
IUPHAR | N/A |
BindingDB | 77970 |
DrugBank | DB01242 |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.04 nM | PMID10447960 | BindingDB,ChEMBL |
IC50 | 99.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 15.5 nM | PMID11454918 | BindingDB |
Ki | 40.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 51.4 nM | PMID2905001 | BindingDB |
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