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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Rattus norvegicus (Rat)
Gene	Mchr1
Synonym	SLC-1 MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	P97639
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075228
IUPHAR	280
DrugBank	N/A

Ligand

Name	CHEMBL242901
Molecular formula	C34H43N3O2
IUPAC name	N-[3-[4-[3-(2-methylpropanoylamino)phenyl]piperidin-1-yl]propyl]-2,2-diphenylbutanamide
Molecular weight	525.737
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	6.4
Synonyms	N-(3-{4-[3-(ISOBUTYRYLAMINO)PHENYL]-1-PIPERIDINYL}PROPYL)-2,2-DIPHENYL BUTANAMIDE SCHEMBL5519535 N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)-2,2-diphenylbutanamide BDBM50219041 GDXCCQORISFUQU-UHFFFAOYSA-N N-{3-[4-(3-isobutyrylamino-phenyl)-piperidin-1-yl]-propyl}-2,2-diphenyl-butyramide [ Show all ]
Inchi Key	GDXCCQORISFUQU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H43N3O2/c1-4-34(29-14-7-5-8-15-29,30-16-9-6-10-17-30)33(39)35-21-12-22-37-23-19-27(20-24-37)28-13-11-18-31(25-28)36-32(38)26(2)3/h5-11,13-18,25-27H,4,12,19-24H2,1-3H3,(H,35,39)(H,36,38)
PubChem CID	16755970
ChEMBL	CHEMBL242901
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	190.0 nM	PMID17668921	ChEMBL
Ki	14.0 nM	PMID17668921	ChEMBL

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