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GPCR

NameAlpha-1B adrenergic receptor
SpeciesMus musculus (Mouse)
GeneAdra1b
Synonymalpha1B-adrenoceptor
alpha1B-adrenergic receptor
Alpha-1B adrenoreceptor
Alpha-1B adrenoceptor
alpha 1B-adrenoreceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length514
Amino acid sequenceMNPDLDTGHNTSAPAHWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGCLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTDLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProtP97717
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2486
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3233665
Molecular formulaC26H35ClN4O2
IUPAC name3,5-dimethyl-5-phenyl-1-[5-(4-phenylpiperazin-1-yl)pentyl]imidazolidine-2,4-dione;hydrochloride
Molecular weight471.042
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogPNone
SynonymsBDBM50004522
Inchi KeyGELFDQDYMKEZRK-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H34N4O2.ClH/c1-26(22-12-6-3-7-13-22)24(31)27(2)25(32)30(26)17-11-5-10-16-28-18-20-29(21-19-28)23-14-8-4-9-15-23;/h3-4,6-9,12-15H,5,10-11,16-21H2,1-2H3;1H
PubChem CID90654833
ChEMBLCHEMBL3233665
IUPHARN/A
BindingDB50004522
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Kd48.75 nMPMID24691057ChEMBL

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