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GPCR

NameType-1 angiotensin II receptor
SpeciesOryctolagus cuniculus (Rabbit)
GeneAGTR1
SynonymAngiotensin II type-1 receptor
AT1
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
UniProtP34976
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3948
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL322471
Molecular formulaC36H35N7O3
IUPAC namepropyl N-benzyl-N-[4-oxo-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-6-yl]carbamate
Molecular weight613.722
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP6.2
SynonymsBenzyl-{4-oxo-2-propyl-3-[2''-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-carbamic acid propyl ester
BDBM50041968
Inchi KeyANCYVULDNZYYMG-UHFFFAOYSA-N
Inchi IDInChI=1S/C36H35N7O3/c1-3-10-33-37-32-20-19-28(42(36(45)46-21-4-2)23-25-11-6-5-7-12-25)22-31(32)35(44)43(33)24-26-15-17-27(18-16-26)29-13-8-9-14-30(29)34-38-40-41-39-34/h5-9,11-20,22H,3-4,10,21,23-24H2,1-2H3,(H,38,39,40,41)
PubChem CID44338697
ChEMBLCHEMBL322471
IUPHARN/A
BindingDB50041968
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC502.5 nMPMID8230109BindingDB,ChEMBL

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