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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SMR000354270
Molecular formula	C30H34N4O2
IUPAC name	1-N,3-N-dicyclohexyl-1-N,3-N-dipyridin-2-ylbenzene-1,3-dicarboxamide
Molecular weight	482.628
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	6.1
Synonyms	AC1NNLY6 MolPort-004-002-302 CHEMBL1533238 1-N,3-N-dicyclohexyl-1-N,3-N-dipyridin-2-ylbenzene-1,3-dicarboxamide MLS001017976 AKOS034458836 N1,N3-dicyclohexyl-N1,N3-bis(pyridin-2-yl)benzene-1,3-dicarboxamide HMS2654C05 Z56830717 380459-13-2 MLS003915368 Oprea1_232767 MCULE-1062669494 ZINC9186026 [ Show all ]
Inchi Key	GFMOZPMHGVTGCW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H34N4O2/c35-29(33(25-14-3-1-4-15-25)27-18-7-9-20-31-27)23-12-11-13-24(22-23)30(36)34(26-16-5-2-6-17-26)28-19-8-10-21-32-28/h7-13,18-22,25-26H,1-6,14-17H2
PubChem CID	5047011
ChEMBL	CHEMBL1533238
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	76091.0 nM	PubChem BioAssay data set	ChEMBL

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