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Name | Gastric inhibitory polypeptide receptor |
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Species | Homo sapiens (Human) |
Gene | GIPR |
Synonym | GIP-R GIP receptor Glucose-dependent insulinotropic polypeptide receptor Gippr |
Disease | Type 2 diabetes |
Length | 466 |
Amino acid sequence | MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC |
UniProt | P48546 |
Protein Data Bank | N/A |
GPCR-HGmod model | P48546 |
3D structure model | This predicted structure model is from GPCR-EXP P48546. |
BioLiP | N/A |
Therapeutic Target Database | T41750 |
ChEMBL | CHEMBL4383 |
IUPHAR | 248 |
DrugBank | N/A |
Name | CHEMBL504245 |
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Molecular formula | C32H31F3N4O5 |
IUPAC name | (2R)-3-[[4-[[N-[[4-cyano-3-(trifluoromethyl)phenyl]carbamoyl]-4-cyclohexylanilino]methyl]benzoyl]amino]-2-hydroxypropanoic acid |
Molecular weight | 608.618 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 4 |
XlogP | 5.5 |
Synonyms | (R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2-hydroxypropionic acid BDBM50245061 SCHEMBL2651818 (R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoyl-amino}-2-hydroxypropionic acid ANMUHQCUTMTNRH-MUUNZHRXSA-N |
Inchi Key | ANMUHQCUTMTNRH-MUUNZHRXSA-N |
Inchi ID | InChI=1S/C32H31F3N4O5/c33-32(34,35)27-16-25(13-10-24(27)17-36)38-31(44)39(26-14-11-22(12-15-26)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(41)37-18-28(40)30(42)43/h6-16,21,28,40H,1-5,18-19H2,(H,37,41)(H,38,44)(H,42,43)/t28-/m1/s1 |
PubChem CID | 10282370 |
ChEMBL | CHEMBL504245 |
IUPHAR | N/A |
BindingDB | 50245061 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 198.0 nM | PMID18707090 | BindingDB,ChEMBL |
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