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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Trace amine-associated receptor 1
Species	Macaca mulatta (Rhesus macaque)
Gene	TAAR1
Synonym	TaR-1 Trace amine receptor 1
Disease	N/A for non-human GPCRs
Length	338
Amino acid sequence	MPFCHNIINISCVKNNWSNDVRASLYSLMALIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKINILVVCVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLAFMTSFYIPGSIMLCIYYRIYLIAKEQARSINDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFVCTVIDPFLHYTIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMILFGKIFQKDSSRCKLFLESSS
UniProt	Q8HZ64
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1926495
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	(+)-Paredrine
Molecular formula	C9H13NO
IUPAC name	4-[(2S)-2-aminopropyl]phenol
Molecular weight	151.209
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.4
Synonyms	7UDF5TX27X d-p-hydroxy-alpha-methylphenethylamine UNII-FQR280JW2N component GIKNHHRFLCDOEU-SSDOTTSWSA-N (S)-P-Hydroxyamphetamine BDBM50359501 p-Hydroxyphenylisopropylamine (+)-4-Hydroxyamphetamine 4-[(2S)-2-aminopropyl]phenol d-1-p-hydroxyphenyl-2-propylamine SCHEMBL256809 (+)-Paredrinex AC1LD8EI d-p-Hydroxyamphetamine UNII-FQR280JW2N component GIKNHHRFLCDOEU-ZETCQYMHSA-N 1693-66-9 Phenol, 4-((2S)-2-aminopropyl)- (+)-p-Hydroxyamphetamine D-4-Hydroxyamphetamine UNII-7UDF5TX27X (S)-4-(2-AMINOPROPYL)PHENOL AKOS027332706 DTXSID10349250 ZINC1690604 4-Hydroxy-dextroamphetamine CHEMBL1927024 phenol, 4-[(2S)-2-aminopropyl]- [ Show all ]
Inchi Key	GIKNHHRFLCDOEU-ZETCQYMHSA-N
Inchi ID	InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
PubChem CID	644000
ChEMBL	CHEMBL1927024
IUPHAR	N/A
BindingDB	50359501
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	101.0 nM	PMID22037049	BindingDB,ChEMBL

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