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Name | Melanin-concentrating hormone receptor 1 |
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Species | Homo sapiens (Human) |
Gene | MCHR1 |
Synonym | SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R [ Show all ] |
Disease | Obesity Obesity; Anxiety; Depression |
Length | 422 |
Amino acid sequence | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT |
UniProt | Q99705 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q99705 |
3D structure model | This predicted structure model is from GPCR-EXP Q99705. |
BioLiP | N/A |
Therapeutic Target Database | T09572 |
ChEMBL | CHEMBL344 |
IUPHAR | 280 |
DrugBank | BE0003478 |
Name | CHEMBL377321 |
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Molecular formula | C28H27F2N3O |
IUPAC name | 4-[4-(3-cyanophenyl)phenyl]-N-(3,4-difluorophenyl)-4-piperidin-4-ylbutanamide |
Molecular weight | 459.541 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 5.0 |
Synonyms | BDBM50186811 4a-(3''-cyano-biphenyl-4-yl)-N-(3,4-difluoro-phenyl)-4-piperidin-4-yl-butyramide |
Inchi Key | GIUBHWVMASIGPO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H27F2N3O/c29-26-10-8-24(17-27(26)30)33-28(34)11-9-25(22-12-14-32-15-13-22)21-6-4-20(5-7-21)23-3-1-2-19(16-23)18-31/h1-8,10,16-17,22,25,32H,9,11-15H2,(H,33,34) |
PubChem CID | 44412852 |
ChEMBL | CHEMBL377321 |
IUPHAR | N/A |
BindingDB | 50186811 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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Ki | 1.2 nM | PMID16690312 | BindingDB,ChEMBL |
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