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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cholecystokinin receptor type A
Species	Rattus norvegicus (Rat)
Gene	Cckar
Synonym	CCK-A receptor CCK-AR CCK1 receptor CCK1-R cholecystokinin receptor type A cholecystokinin-1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
UniProt	P30551
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2871
IUPHAR	76
DrugBank	N/A

Ligand

Name	CHEMBL1933109
Molecular formula	C26H23N3O4
IUPAC name	2-[[2-(1H-indole-2-carbonylamino)phenyl]carbamoyl]-4-phenylbutanoic acid
Molecular weight	441.487
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	5.0
Synonyms	BDBM50360278
Inchi Key	ANRSZDYEQUXIQO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H23N3O4/c30-24(19(26(32)33)15-14-17-8-2-1-3-9-17)28-21-12-6-7-13-22(21)29-25(31)23-16-18-10-4-5-11-20(18)27-23/h1-13,16,19,27H,14-15H2,(H,28,30)(H,29,31)(H,32,33)
PubChem CID	53465907
ChEMBL	CHEMBL1933109
IUPHAR	N/A
BindingDB	50360278
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	717.0 nM	PMID21728335	BindingDB,ChEMBL

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