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Name | Alpha-1A adrenergic receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Adra1a |
Synonym | alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV |
UniProt | P43140 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL319 |
IUPHAR | 22 |
DrugBank | N/A |
Name | clonidine |
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Molecular formula | C9H9Cl2N3 |
IUPAC name | N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine |
Molecular weight | 230.092 |
Hydrogen bond acceptor | 1 |
Hydrogen bond donor | 2 |
XlogP | 1.6 |
Synonyms | clonidine (amino form) 2-Imidazoline, 2-(2,6-dichloroanilino)-(7CI,8CI) Clonidinhydrochlorid 4205-90-7 D03SKR [ Show all ] |
Inchi Key | GJSURZIOUXUGAL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) |
PubChem CID | 2803 |
ChEMBL | CHEMBL134 |
IUPHAR | 516 |
BindingDB | 50016897 |
DrugBank | DB00575 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 372.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Intrinsic activity | 0.83 - | PMID1956038 | ChEMBL |
Kd | 257.04 nM | PMID1956038 | BindingDB,ChEMBL |
Ki | 5.7 nM | PMID17827 | BindingDB |
Ki | 100.0 nM | PMID11082457 | BindingDB |
Ki | 151.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 430.0 nM | PMID17827 | BindingDB |
pD2 | 7.84 - | PMID1956038 | ChEMBL |
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