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GPCR

NameBeta-3 adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdrb3
Synonymbeta3-adrenoceptor
beta3-adrenergic receptor
Beta-3 adrenoreceptor
Beta-3 adrenoceptor
ADRB
[ Show all ]
DiseaseN/A for non-human GPCRs
Length400
Amino acid sequenceMAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
UniProtP26255
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4031
IUPHAR30
DrugBankN/A

Ligand

NameCHEMBL48632
Molecular formulaC23H32N2O5
IUPAC nameN,N-diethyl-2-[4-[2-[(2-hydroxy-3-phenoxypropyl)amino]ethoxy]phenoxy]acetamide
Molecular weight416.518
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.4
Synonyms[4-[2-[2-Hydroxy-3-(phenoxy)propylamino]ethoxy]phenoxy]-N,N-diethylacetamide
Inchi KeyGLJAQQFMWIZSSR-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H32N2O5/c1-3-25(4-2)23(27)18-30-22-12-10-21(11-13-22)28-15-14-24-16-19(26)17-29-20-8-6-5-7-9-20/h5-13,19,24,26H,3-4,14-18H2,1-2H3
PubChem CID15174964
ChEMBLCHEMBL48632
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
GDP ED501.16 mg kg-1PMID1350310ChEMBL

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