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GPCR

NameHistamine H3 receptor
SpeciesMus musculus (Mouse)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtP58406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3263
IUPHAR264
DrugBankN/A

Ligand

NameCHEMBL129493
Molecular formulaC25H33N3O6
IUPAC name(Z)-but-2-enedioic acid;1-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]-4-piperidin-1-ylbutan-1-one
Molecular weight471.554
Hydrogen bond acceptor8
Hydrogen bond donor3
XlogPNone
SynonymsN/A
Inchi KeyGLNSREMMEFZYGI-BTJKTKAUSA-N
Inchi IDInChI=1S/C21H29N3O2.C4H4O4/c25-21(7-4-14-24-12-2-1-3-13-24)18-8-10-20(11-9-18)26-15-5-6-19-16-22-17-23-19;5-3(6)1-2-4(7)8/h8-11,16-17H,1-7,12-15H2,(H,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-
PubChem CID44352037
ChEMBLCHEMBL129493
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
ED50<10.0 mg.kg-1PMID11052804ChEMBL

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