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GPCR

Name5-hydroxytryptamine receptor 6
SpeciesHomo sapiens (Human)
GeneHTR6
Synonym5-HT6 receptor
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
5-HT-6
serotonin receptor 6
ST-B17
[ Show all ]
DiseaseSchizophrenia
Obesity
Neurological disease
Neurodegenerative disease
Emesis
[ Show all ]
Length440
Amino acid sequenceMVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProtP50406
Protein Data BankN/A
GPCR-HGmod modelP50406
3D structure modelThis predicted structure model is from GPCR-EXP P50406.
BioLiPN/A
Therapeutic Target DatabaseT16691
ChEMBLCHEMBL3371
IUPHAR11
DrugBankBE0000945

Ligand

Nametolylpiperidine, 9g
Molecular formulaC18H22N2O
IUPAC name3-[(2-methyl-3-piperidin-4-ylphenoxy)methyl]pyridine
Molecular weight282.387
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.8
SynonymsBDBM28600
3-[2-methyl-3-(piperidin-4-yl)phenoxymethyl]pyridine
CHEMBL449581
Inchi KeyANXSUZBBWPTUDU-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H22N2O/c1-14-17(16-7-10-19-11-8-16)5-2-6-18(14)21-13-15-4-3-9-20-12-15/h2-6,9,12,16,19H,7-8,10-11,13H2,1H3
PubChem CID25263319
ChEMBLCHEMBL449581
IUPHARN/A
BindingDB28600
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<440.0 nMPMID19346128BindingDB,ChEMBL

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