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| Name | 5-hydroxytryptamine receptor 6 |
|---|---|
| Species | Rattus norvegicus (Rat) |
| Gene | Htr6 |
| Synonym | 5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 [ Show all ] |
| Disease | N/A for non-human GPCRs |
| Length | 436 |
| Amino acid sequence | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP |
| UniProt | P31388 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL3372 |
| IUPHAR | 11 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 9290 |  CHEMBL1949768 | C20H24ClNO4S | 409.925 | 5 / 2 | N/A | N/A |
| 11058 |  tryptamine | C10H12N2 | 160.22 | 1 / 2 | 1.6 | Yes |
| 13549 |  N-Methylserotonin | C11H14N2O | 190.246 | 2 / 3 | 0.7 | Yes |
| 20183 |  imipramine | C19H24N2 | 280.415 | 2 / 0 | 4.8 | Yes |
| 20937 |  SB-258585 | C18H22IN3O3S | 487.356 | 6 / 1 | 3.0 | Yes |
| 21234 |  (RS)-PPCC | C24H29NO3 | 379.5 | 4 / 1 | 3.5 | Yes |
| 22322 |  CHEMBL363466 | C20H25NO2 | 311.425 | 3 / 0 | 4.2 | Yes |
| 23360 |  sulpiride | C15H23N3O4S | 341.426 | 6 / 2 | 0.6 | Yes |
| 553387 |  LISURIDE | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 26059 |  S-(-)-Lisuride | C20H26N4O | 338.455 | 2 / 2 | 2.7 | Yes |
| 27042 |  SB-357134 | C17H18Br2FN3O3S | 523.215 | 7 / 2 | 3.4 | No |
| 34498 |  CHEMBL1935600 | C20H18FNO4S | 387.425 | 6 / 1 | 2.5 | Yes |
| 522601 |  CHEMBL3797434 | C26H30N6O3 | 474.565 | 6 / 1 | 3.2 | Yes |
| 38408 |  CHEMBL1949765 | C18H19NO3S | 329.414 | 4 / 1 | 2.6 | Yes |
| 40303 |  Aripiprazole | C23H27Cl2N3O2 | 448.388 | 4 / 1 | 4.6 | Yes |
| 46810 |  CHEMBL1949760 | C17H16FNO3S | 333.377 | 5 / 1 | 2.4 | Yes |
| 553533 |  NSC409663 | C35H41N5O5 | 611.743 | 6 / 3 | 3.3 | No |
| 523263 |  CHEMBL3797890 | C28H33N3O2 | 443.591 | 2 / 2 | 5.6 | No |
| 523297 |  CHEMBL3797957 | C24H25ClN6O | 448.955 | 4 / 1 | 3.9 | Yes |
| 60590 |  CHEMBL1949930 | C21H25NO5S | 403.493 | 6 / 1 | 3.0 | Yes |
| 62220 |  spiperone | C23H26FN3O2 | 395.478 | 5 / 1 | 3.0 | Yes |
| 62404 |  MELPERONE | C16H22FNO | 263.356 | 3 / 0 | 3.3 | Yes |
| 523492 |  CHEMBL3798243 | C24H32N6O | 420.561 | 4 / 1 | 4.0 | Yes |
| 68281 |  CHEMBL1935598 | C20H20FNO4S | 389.441 | 6 / 1 | 2.7 | Yes |
| 553620 |  S-16924 | C22H24FNO4 | 385.435 | 6 / 0 | 3.4 | Yes |
| 76127 |  CHEMBL1949773 | C17H15F2NO3S | 351.368 | 6 / 1 | 2.5 | Yes |
| 83893 |  Ketanserin | C22H22FN3O3 | 395.434 | 5 / 1 | 2.6 | Yes |
| 86479 |  4'-Aminopropiophenone | C9H11NO | 149.193 | 2 / 1 | 1.7 | Yes |
| 553713 |  PAPP | C19H22F3N3 | 349.401 | 6 / 1 | 4.0 | Yes |
| 93730 |  clomipramine | C19H23ClN2 | 314.857 | 2 / 0 | 5.2 | No |
| 94905 |  thiothixene | C23H29N3O2S2 | 443.624 | 6 / 0 | 3.8 | Yes |
| 98854 |  CHEMBL1949764 | C17H16ClNO3S | 349.829 | 4 / 1 | 2.9 | Yes |
| 105468 |  AC1L1JJR | C21H27N3 | 321.468 | 2 / 1 | 3.9 | Yes |
| 105651 |  Remoxipride | C16H23BrN2O3 | 371.275 | 4 / 1 | 2.1 | Yes |
| 109142 |  SERTINDOLE | C24H26ClFN4O | 440.947 | 3 / 1 | 4.1 | Yes |
| 112157 |  zotepine | C18H18ClNOS | 331.858 | 3 / 0 | 4.8 | Yes |
| 116139 |  Bufotenium | C13H19N2O+ | 219.308 | 1 / 2 | 1.2 | Yes |
| 117080 |  CHEMBL1935589 | C17H15NO3S | 313.371 | 4 / 1 | 2.6 | Yes |
| 119446 |  CHEMBL313714 | C26H31FN6O | 462.573 | 6 / 3 | 2.9 | Yes |
| 525068 |  CHEMBL3799903 | C26H31N3O4 | 449.551 | 4 / 2 | 3.5 | Yes |
| 122829 |  NAE-111 | C16H24N2O2 | 276.38 | 3 / 1 | 2.6 | Yes |
| 125786 |  CHEMBL1949762 | C23H22ClNO3S | 427.943 | 4 / 2 | N/A | N/A |
| 126639 |  Volinanserin | C22H28FNO3 | 373.468 | 5 / 1 | 3.9 | Yes |
| 128590 |  CHEMBL193400 | C18H17Cl2N3O2S | 410.313 | 4 / 1 | 4.0 | Yes |
| 134371 |  CHEMBL1949761 | C17H16ClNO3S | 349.829 | 4 / 1 | 2.9 | Yes |
| 135745 |  CHEMBL1949930 | C21H26ClNO5S | 439.951 | 6 / 2 | N/A | N/A |
| 136353 |  CHEMBL1935588 | C17H15NO3S | 313.371 | 4 / 1 | 2.6 | Yes |
| 137107 |  CHEMBL1949762 | C23H21NO3S | 391.485 | 4 / 1 | 3.9 | Yes |
| 148102 |  CHEMBL1744087 | C20H30N2O7S | 442.527 | 9 / 2 | N/A | N/A |
| 148961 |  Ro 04-6790 | C12H16N6O2S | 308.36 | 8 / 4 | 1.7 | Yes |
| 525836 |  CHEMBL3800049 | C28H26ClN3O2 | 471.985 | 2 / 2 | 5.5 | No |
| 525856 |  CHEMBL3800065 | C25H26N6O3 | 458.522 | 6 / 1 | 3.1 | Yes |
| 152209 |  CYPROHEPTADINE | C21H21N | 287.406 | 1 / 0 | 4.7 | Yes |
| 554028 |  Lergotrile | C17H18ClN3 | 299.802 | 2 / 1 | 3.3 | Yes |
| 152802 |  Lergotrile [USAN:INN] | C17H18ClN3 | 299.802 | 2 / 1 | 3.3 | Yes |
| 154024 |  Mesulergine | C18H26N4O2S | 362.492 | 5 / 1 | 1.4 | Yes |
| 155302 |  Dimebolin | C21H25N3 | 319.452 | 2 / 0 | 3.5 | Yes |
| 159335 |  5-METHOXYTRYPTAMINE | C11H14N2O | 190.246 | 2 / 2 | 0.5 | Yes |
| 160344 |  ritanserin | C27H25F2N3OS | 477.574 | 6 / 0 | 5.2 | No |
| 164173 |  Clothiapine | C18H18ClN3S | 343.873 | 3 / 0 | 3.6 | Yes |
| 170375 |  CHEMBL1949763 | C17H17ClFNO3S | 369.835 | 5 / 2 | N/A | N/A |
| 526359 |  CHEMBL3798364 | C24H26BrN3O2 | 468.395 | 2 / 2 | 4.2 | Yes |
| 170655 |  CHEMBL1935597 | C19H16F3NO3S | 395.396 | 7 / 1 | 3.7 | Yes |
| 171173 |  15532-75-9 | C11H13F3N2 | 230.234 | 5 / 1 | 2.3 | Yes |
| 171778 |  thioridazine | C21H26N2S2 | 370.573 | 4 / 0 | 5.9 | No |
| 172220 |  MOLINDONE | C16H24N2O2 | 276.38 | 3 / 1 | 1.7 | Yes |
| 174864 |  methysergide | C21H27N3O2 | 353.466 | 3 / 2 | 2.3 | Yes |
| 175653 |  sumatriptan | C14H21N3O2S | 295.401 | 4 / 2 | 0.9 | Yes |
| 176236 |  CHEMBL1949772 | C18H20ClNO3S | 365.872 | 4 / 2 | N/A | N/A |
| 176426 |  amitriptyline | C20H23N | 277.411 | 1 / 0 | 5.0 | Yes |
| 526511 |  CHEMBL3798013 | C26H32N4O2 | 432.568 | 3 / 2 | 3.7 | Yes |
| 484902 |  CHEMBL365751 | C13H17ClN2 | 236.743 | 1 / 1 | 3.4 | Yes |
| 179152 |  CHEMBL515624 | C18H17ClN2O2S | 360.856 | 3 / 1 | 3.7 | Yes |
| 563064 |  CHEMBL61861 | C19H19F3NO3- | 366.36 | 7 / 0 | 2.5 | Yes |
| 182742 |  CHEMBL1949761 | C17H17Cl2NO3S | 386.287 | 4 / 2 | N/A | N/A |
| 185893 |  Chlorpromazine N-oxide | C17H19ClN2OS | 334.862 | 3 / 0 | 4.6 | Yes |
| 191574 |  haloperidol | C21H23ClFNO2 | 375.868 | 4 / 1 | 3.2 | Yes |
| 192212 |  SB-271046 | C20H22ClN3O3S2 | 451.984 | 7 / 2 | 4.2 | Yes |
| 554283 |  dihydroergotamine | C33H37N5O5 | 583.689 | 6 / 3 | 2.4 | No |
| 197114 |  SCHEMBL12586671 | C33H37N5O5 | 583.689 | 6 / 3 | 2.4 | No |
| 198693 |  CGS 12066B | C17H17F3N4 | 334.346 | 6 / 0 | 4.0 | Yes |
| 554291 |  alpha-methyl-5-HT | C11H14N2O | 190.246 | 2 / 3 | 0.6 | Yes |
| 202771 |  PENFLURIDOL | C28H27ClF5NO | 523.972 | 7 / 1 | 7.3 | No |
| 212007 |  Robalzotan BNAD 299 HCL | C18H23FN2O2 | 318.392 | 4 / 1 | 2.8 | Yes |
| 527656 |  CHEMBL3799279 | C26H27ClN6O | 474.993 | 4 / 1 | 4.7 | Yes |
| 216301 |  CHEMBL1935599 | C21H20FNO4S | 401.452 | 6 / 1 | 2.9 | Yes |
| 527798 |  CHEMBL3797813 | C24H26ClN3O2 | 423.941 | 2 / 2 | 4.2 | Yes |
| 219831 |  N-Methyltryptamine | C11H14N2 | 174.247 | 1 / 2 | 2.1 | Yes |
| 223479 |  CHEMBL1949764 | C17H17Cl2NO3S | 386.287 | 4 / 2 | N/A | N/A |
| 227461 |  Amperozide | C23H29F2N3O | 401.502 | 4 / 1 | 4.1 | Yes |
| 528126 |  CHEMBL3797430 | C28H32N6O | 468.605 | 4 / 1 | 5.5 | No |
| 237421 |  FLUPERLAPINE | C19H20FN3 | 309.388 | 3 / 0 | 2.9 | Yes |
| 238706 |  doxepin | C19H21NO | 279.383 | 2 / 0 | 4.3 | Yes |
| 251073 |  CHEMBL1935601 | C21H20FNO4S | 401.452 | 6 / 1 | 2.9 | Yes |
| 554527 |  bromocriptine | C32H40BrN5O5 | 654.606 | 6 / 3 | 3.8 | No |
| 254469 |  SB-214111 | C18H22BrN3O3S | 440.356 | 6 / 1 | 3.0 | Yes |
| 255944 |  Dihydroergocryptine | C32H43N5O5 | 577.726 | 6 / 3 | 3.1 | No |
| 256365 |  CHEMBL1949765 | C18H20ClNO3S | 365.872 | 4 / 2 | N/A | N/A |
| 260139 |  nortriptyline | C19H21N | 263.384 | 1 / 1 | 4.5 | Yes |
| 262508 |  FLUPHENAZINE | C22H26F3N3OS | 437.525 | 8 / 1 | 4.4 | Yes |
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