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GPCR

NameMetabotropic glutamate receptor 2
SpeciesRattus norvegicus (Rat)
GeneGrm2
Synonymglutamate receptor
GPRC1B
metabotropic glutamate receptor 2
mGlu2 receptor
mGluR2
DiseaseN/A for non-human GPCRs
Length872
Amino acid sequenceMESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProtP31421
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2851
IUPHAR290
DrugBankN/A

Known ligands

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Total entries: 628
Page:  / 7 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
1102D structureCHEMBL278949C13H15NO5265.2656 / 3-1.6Yes
2302D structureCHEMBL3287722C23H28O6400.4716 / 25.2No
9382D structureCHEMBL3288658C24H18BrN3O2460.3313 / 05.3No
12272D structureCHEMBL69204C16H12Cl2N4O347.1994 / 04.2Yes
13582D structureCHEMBL188511C15H14F3NO5345.2749 / 3-1.7Yes
44312D structureCHEMBL1629856C25H22F3N3O437.4666 / 15.5No
58972D structureCHEMBL3287694C25H29FO6444.4997 / 26.3No
66502D structureCHEMBL236035C23H15IN2O462.292 / 15.1No
67132D structureCHEMBL334842C6H9N3O3S203.2166 / 3-3.4Yes
67162D structureCHEMBL131922C6H9N3O3S203.2166 / 3-3.4Yes
75582D structureCHEMBL270402C27H22N6O446.5145 / 14.0Yes
86922D structureCHEMBL607689C20H22FN3323.4153 / 03.6Yes
92592D structureCHEMBL2179623C24H17ClNNaO4S473.9035 / 0N/AN/A
4593012D structureCHEMBL543097C14H18N2O5294.3077 / 3-4.6Yes
107152D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
5217712D structureCHEMBL2312685C8H16N2O4204.2266 / 4-6.8Yes
116632D structureCHEMBL3287674C26H32O5424.5375 / 16.3No
122552D structureCHEMBL477170C21H22ClN3O367.8773 / 03.9Yes
129092D structureVU 0361737C13H11ClN2O2262.6933 / 12.6Yes
133142D structureQUISQUALIC ACIDC5H7N3O5189.1276 / 3-3.9Yes
150422D structureCHEMBL197629C7H10N2O5202.1667 / 3-3.4Yes
160262D structureCHEMBL367027C12H12N2O5264.2376 / 4-2.3Yes
165622D structureCHEMBL3287725C25H32O6428.5256 / 26.1No
175552D structureCHEMBL1629845C23H18F3N3O409.4126 / 14.6Yes
181482D structureCHEMBL304285C13H13Cl2N3O298.1673 / 03.9Yes
186282D structureCHEMBL3287682C26H31ClO5458.9795 / 17.0No
193422D structureCHEMBL362325C15H14ClF2NO5361.7268 / 3-1.2Yes
194072D structureCHEMBL185210C19H18FNO5359.3537 / 3-0.7Yes
203142D structureCHEMBL319279C28H27NO5457.5266 / 32.1Yes
217762D structureCHEMBL68739C18H21Cl2N3O366.2863 / 06.0No
219302D structureCHEMBL3287680C25H30O6426.5096 / 26.2No
223942D structureCHEMBL479804C8H14N2O5218.2096 / 4-3.3Yes
227072D structureCHEMBL364201C19H18FNO5359.3537 / 3-0.7Yes
238072D structureCHEMBL3288657C23H16BrN3O430.3052 / 05.3No
5222592D structureCHEMBL3786667C8H11NO6217.1777 / 4-4.0Yes
5222702D structureCHEMBL3787264C8H11NO6217.1777 / 4-4.0Yes
5222782D structureCHEMBL3786026C8H11NO6217.1777 / 4-4.0Yes
5222902D structureCHEMBL3786938C8H11NO6217.1777 / 4-4.0Yes
279922D structureCHEMBL271319C28H22N4O430.5113 / 15.0Yes
293262D structureCHEMBL1774224C21H23F3N4388.4386 / 04.1Yes
294032D structureCHEMBL3286420C23H16FN3O369.3993 / 04.7Yes
301312D structureCHEMBL541050C13H20Cl3N3O4388.677 / 7N/ANo
314622D structureCHEMBL1629846C25H20F3N3O435.456 / 14.8Yes
321842D structureCHEMBL3287675C23H28O6400.4716 / 25.3No
322452D structureCHEMBL3288655C24H18ClN3O2415.8773 / 05.2No
335192D structureCHEMBL2179631C28H27NO5457.5265 / 14.8Yes
357112D structureCHEMBL144201C8H9F2NO4221.167 / 3-2.9Yes
360782D structureCHEMBL539760C13H17Cl2N3O6382.1948 / 5N/AN/A
372422D structureCHEMBL3287692C26H32O6440.5366 / 26.5No
374592D structureCHEMBL242344C12H19N3O3253.3025 / 3-0.3Yes
383972D structureCHEMBL361051C15H14F3NO5345.2749 / 3-1.7Yes
4595742D structureCHEMBL538487C13H16N2O5280.287 / 4-4.9Yes
402352D structureCHEMBL405895C24H17FN4O2412.4245 / 23.5Yes
420262D structureCHEMBL256424C29H24FN5O2493.5426 / 23.7Yes
422742D structureCHEMBL1631860C24H20F3N3O423.4396 / 15.1No
426522D structureCHEMBL484578C20H21ClN4O368.8654 / 02.9Yes
428532D structureAC1MWWXCC7H14NO6P239.1647 / 4-4.8Yes
437392D structureCHEMBL3287709C22H26O7402.4437 / 24.5Yes
443732D structureCHEMBL1209401C26H33ClN2O3457.0114 / 18.2No
454652D structureCHEMBL1629864C21H15Cl2N3O396.2713 / 14.6Yes
471392D structureCHEMBL477375C21H21ClFN3O385.8674 / 04.0Yes
484032D structureCHEMBL1774235C21H22F4N4O422.4288 / 04.5Yes
484052D structureCHEMBL1774236C21H22F4N4O422.4288 / 04.5Yes
505462D structureCHEMBL259340C19H14F3N5O2401.3498 / 12.7Yes
506352D structureCHEMBL3288644C22H15FN4O370.3874 / 03.6Yes
526162D structureCHEMBL3287726C24H29FO6432.4887 / 25.8No
537552D structureCHEMBL3287719C23H28O7416.477 / 24.8Yes
4597332D structureCHEMBL543811C12H15N3O4265.2697 / 3-5.6Yes
570022D structureCHEMBL263649C21H18F3N5O413.4047 / 13.2Yes
572842D structureL-AP4C4H10NO5P183.16 / 4-5.5Yes
586872D structureCHEMBL389585C8H13N3O3199.215 / 3-2.1Yes
589642D structureCHEMBL1629865C22H16F3N3O395.3856 / 14.3Yes
592492D structureCHEMBL3288666C24H18ClN3O2415.8773 / 05.2No
593302D structureCHEMBL3288637C23H17N3O351.4092 / 04.6Yes
596772D structureCHEMBL604467C21H22F3N3373.4235 / 04.4Yes
601122D structureCHEMBL260343C17H12BrN5O382.2214 / 12.5Yes
602772D structureCHEMBL363980C15H14Cl2FNO5378.1777 / 3-0.7Yes
611542D structureCHEMBL341888C8H10FNO4203.1696 / 3-3.2Yes
611552D structureCHEMBL334014C8H10FNO4203.1696 / 3-3.2Yes
611652D structureCHEMBL144678C8H10FNO4203.1696 / 3-3.2Yes
614562D structureCHEMBL476791C27H27N3O409.5333 / 04.9Yes
623512D structureCHEMBL1631865C27H24F3N3O463.5046 / 15.9No
628122D structureCHEMBL183956C9H12FNO5233.1957 / 3-3.4Yes
628142D structureCHEMBL185135C9H12FNO5233.1957 / 3-3.4Yes
630912D structureCHEMBL400018C24H18N2O2366.423 / 14.4Yes
4597922D structureCHEMBL539516C21H20N2O4364.4016 / 3-2.5Yes
636062D structureCHEMBL362092C15H15ClFNO5343.7357 / 3-1.3Yes
640912D structureCHEMBL181710C18H20Cl2FNO5420.2587 / 30.6Yes
640922D structureCHEMBL365680C18H20Cl2FNO5420.2587 / 30.6Yes
5535642D structure(S)-MCPGC10H11NO4209.2015 / 3-2.0Yes
642282D structure(RS)-MCPGC10H11NO4209.2015 / 3-2.0Yes
652042D structureCHEMBL69869C13H13F2N3O265.2645 / 02.9Yes
653472D structureCHEMBL3287697C23H27ClO6434.9136 / 25.9No
664312D structureCID 40428795C8H9NO3167.1643 / 2-1.4Yes
4598262D structureCHEMBL544508C13H15N3O6309.2788 / 3-4.7Yes
666492D structureCHEMBL184983C17H18Cl2FNO5406.2317 / 30.3Yes
666502D structureCHEMBL185423C17H18Cl2FNO5406.2317 / 30.3Yes
684132D structureCHEMBL3287721C22H25FO6404.4347 / 25.0Yes
684402D structureCHEMBL515034C21H21F3N4O402.4217 / 03.4Yes
692782D structureCHEMBL3288680C26H18N4O402.4573 / 04.8Yes

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