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Name | Metabotropic glutamate receptor 5 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM5 |
Synonym | mGlu5 receptor glutamate receptor GPRC1E mGluR5 |
Disease | Central nervous system disease Chronic neuropathic pain Fragile X syndrome Major depressive disorder; GERD; Chronic neuropathic pain Autism [ Show all ] |
Length | 1212 |
Amino acid sequence | MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL |
UniProt | P41594 |
Protein Data Bank | 4oo9, 5cgc, 5cgd, 6ffh, 6ffi, 6n4x, 6n4y, 6n50, 6n51, 3lmk |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 4oo9. |
BioLiP | BL0176927,BL0176931, BL0176928,BL0176929,BL0176930, BL0281199, BL0322076, BL0322077, BL0407724, BL0438693, BL0438694, BL0438695,BL0438696,BL0438697, BL0407725, BL0438698,BL0438699 |
Therapeutic Target Database | T99347 |
ChEMBL | CHEMBL3227 |
IUPHAR | 293 |
DrugBank | BE0001192 |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
521449 | CHEMBL3739885 | C9H5BrClN3OS | 318.573 | 4 / 1 | 3.4 | Yes |
648 | CHEMBL215957 | C18H19NO | 265.356 | 2 / 0 | 4.3 | Yes |
459240 | CHEMBL3655617 | C17H11N5O2 | 317.308 | 6 / 1 | 1.5 | Yes |
905 | CHEMBL2151617 | C18H18F3N3O2 | 365.356 | 7 / 0 | 3.1 | Yes |
1086 | CHEMBL246041 | C15H12N2O3 | 268.272 | 3 / 2 | 2.3 | Yes |
521473 | CHEMBL3742147 | C10H5ClN4OS | 264.687 | 5 / 1 | 2.4 | Yes |
535945 | CHEMBL3982481 | C19H18FN3O | 323.371 | 4 / 0 | 2.2 | Yes |
1207 | SCHEMBL6918188 | C17H13ClN4O3 | 356.766 | 6 / 1 | 2.8 | Yes |
1219 | CHEMBL184047 | C17H11FN6S | 350.375 | 7 / 0 | 3.5 | Yes |
1538 | BDBM50201676 | C11H13N5O2 | 247.258 | 4 / 3 | 0.2 | Yes |
521501 | CHEMBL3736163 | C18H22N6O | 338.415 | 6 / 0 | 2.3 | Yes |
2101 | CHEMBL2346732 | C18H14F4N4O | 378.331 | 7 / 1 | 3.9 | Yes |
2195 | CHEMBL1784103 | C17H14ClFN2O3 | 348.758 | 6 / 1 | 3.9 | Yes |
2931 | CHEMBL224615 | C17H14N4OS | 322.386 | 5 / 0 | 3.2 | Yes |
441856 | CHEMBL3410212 | C17H11N3O | 273.295 | 3 / 0 | 2.2 | Yes |
536022 | SCHEMBL2520315 | C19H18ClN3O | 339.823 | 2 / 0 | 3.6 | Yes |
4033 | Acamprosate | C5H11NO4S | 181.206 | 4 / 2 | -1.2 | Yes |
4245 | CHEMBL1783868 | C20H18N4OS | 362.451 | 5 / 1 | 4.7 | Yes |
4404 | CHEMBL2403653 | C18H19N3O2S2 | 373.489 | 6 / 0 | 2.6 | Yes |
5150 | CHEMBL2403667 | C18H16N2OS | 308.399 | 3 / 0 | 3.7 | Yes |
5302 | CHEMBL595943 | C17H18ClN3O | 315.801 | 3 / 1 | 3.7 | Yes |
5810 | CHEMBL1808881 | C21H23ClN2O | 354.878 | 2 / 0 | 4.3 | Yes |
459277 | CHEMBL3655594 | C18H13N5O2 | 331.335 | 6 / 1 | 1.9 | Yes |
6345 | CHEMBL185813 | C13H11NS | 213.298 | 2 / 0 | 3.8 | Yes |
441959 | CHEMBL334842 | C6H9N3O3S | 203.216 | 6 / 3 | -3.4 | Yes |
441961 | CHEMBL131922 | C6H9N3O3S | 203.216 | 6 / 3 | -3.4 | Yes |
6751 | CHEMBL2113099 | C21H16N2O2 | 328.371 | 3 / 0 | 2.9 | Yes |
6815 | CHEMBL1779857 | C15H12N2OS | 268.334 | 3 / 0 | 2.2 | Yes |
536111 | CHEMBL3939809 | C20H18F2N2O | 340.374 | 4 / 0 | 3.3 | Yes |
536112 | SCHEMBL2518446 | C19H18N2O2 | 306.365 | 3 / 1 | 2.9 | Yes |
7026 | CHEMBL181424 | C13H14N4O | 242.282 | 4 / 2 | 2.0 | Yes |
536141 | CHEMBL3899832 | C22H19N5O4 | 417.425 | 8 / 2 | 3.6 | Yes |
7203 | CHEMBL238262 | C17H11N5OS | 333.369 | 5 / 1 | 3.1 | Yes |
536161 | SCHEMBL2520891 | C18H17N3O | 291.354 | 3 / 0 | 2.4 | Yes |
7429 | 3-methyl-N-(6-methylpyridin-2-yl)benzamide | C14H14N2O | 226.279 | 2 / 1 | 2.8 | Yes |
7791 | CHEMBL224322 | C21H24N4OS | 380.51 | 5 / 0 | 4.3 | Yes |
7817 | CHEMBL594296 | C18H19Cl2N3O | 364.27 | 3 / 1 | 4.7 | Yes |
7836 | CHEMBL2426602 | C19H22N2O3S | 358.456 | 5 / 0 | 2.9 | Yes |
536173 | SCHEMBL2959176 | C19H18N6O3 | 378.392 | 7 / 1 | 1.2 | Yes |
7880 | Quinoline,2-[2-(5-fluoro-2-pyrimidinyl)ethynyl]- | C15H8FN3 | 249.248 | 4 / 0 | 2.7 | Yes |
7995 | CHEMBL386408 | C17H21N5O2S | 359.448 | 6 / 0 | 2.3 | Yes |
8044 | CHEMBL239604 | C13H9ClN4O | 272.692 | 3 / 2 | 2.5 | Yes |
8150 | CHEMBL2338601 | C20H22ClN3O2 | 371.865 | 3 / 2 | 3.8 | Yes |
8262 | CHEMBL2208408 | C15H15ClN2O3S | 338.806 | 4 / 1 | 2.6 | Yes |
8285 | CHEMBL2151622 | C18H21ClN4O2 | 360.842 | 4 / 0 | 3.1 | Yes |
8567 | CHEMBL3122214 | C18H14F2N6O2 | 384.347 | 9 / 0 | 2.2 | Yes |
8568 | 42160-26-9 | C12H10N2S | 214.286 | 3 / 1 | 3.6 | Yes |
536191 | SCHEMBL9926343 | C21H20FN3O2 | 365.408 | 4 / 0 | 2.9 | Yes |
8694 | CHEMBL607689 | C20H22FN3 | 323.415 | 3 / 0 | 3.6 | Yes |
463932 | CHEMBL3605277 | C20H16F2N2O3 | 370.356 | 6 / 0 | 3.1 | Yes |
8735 | CHEMBL1684105 | C21H19NO | 301.389 | 1 / 0 | 4.2 | Yes |
8746 | CHEMBL1771682 | C19H22FN3O2 | 343.402 | 5 / 0 | 3.7 | Yes |
8823 | CHEMBL2153782 | C15H14N4O | 266.304 | 3 / 2 | 2.2 | Yes |
463976 | CHEMBL3603928 | C15H9N5 | 259.272 | 5 / 0 | 1.6 | Yes |
464007 | CHEMBL3605300 | C22H21FN2O3 | 380.419 | 5 / 0 | 3.9 | Yes |
9343 | CHEMBL207097 | C18H17ClN4O | 340.811 | 5 / 0 | 3.6 | Yes |
9621 | CHEMBL1771692 | C20H16F3N3O2 | 387.362 | 7 / 0 | 4.0 | Yes |
547995 | CHEMBL3903257 | C22H21FN2O | 348.421 | 3 / 0 | 3.9 | Yes |
536239 | CHEMBL3924488 | C22H21FN2O | 348.421 | 3 / 0 | 3.9 | Yes |
9953 | CHEMBL363408 | C31H33NO5 | 499.607 | 5 / 0 | 6.3 | No |
9971 | CHEMBL575695 | C21H19NO3S | 365.447 | 4 / 1 | 5.6 | No |
10196 | 2-acetamido-N-(3-chlorophenyl)benzamide | C15H13ClN2O2 | 288.731 | 2 / 2 | 3.8 | Yes |
10208 | BDBM50179661 | C15H18N4O2 | 286.335 | 3 / 3 | 2.0 | Yes |
10401 | CHEMBL2426616 | C14H14N2O2S | 274.338 | 4 / 0 | 2.3 | Yes |
10610 | AC1LSLDP | C14H14N4O2S | 302.352 | 5 / 1 | 2.8 | Yes |
10611 | GSK2210875 | C14H14N4O2S | 302.352 | 5 / 1 | 2.8 | Yes |
10613 | 1-(6-methyl[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamate | C14H14N4O2S | 302.352 | 5 / 1 | 2.8 | Yes |
536263 | SCHEMBL9926434 | C22H19FN4O2 | 390.418 | 5 / 0 | 2.7 | Yes |
10817 | CHEMBL1783862 | C19H15FN4O2S | 382.413 | 7 / 1 | 3.8 | Yes |
11022 | CID 53321026 | C16H10O2 | 234.254 | 2 / 0 | 3.5 | Yes |
464266 | CHEMBL3633967 | C14H16N4O2 | 272.308 | 4 / 0 | 0.4 | Yes |
11689 | SCHEMBL8030897 | C13H12N4O2S | 288.325 | 5 / 1 | 2.4 | Yes |
442161 | CHEMBL3398289 | C19H17N3O3 | 335.363 | 5 / 0 | 2.3 | Yes |
536309 | SCHEMBL2959089 | C18H15ClN6O3 | 398.807 | 7 / 1 | 1.7 | Yes |
12256 | CHEMBL1290788 | C18H21N3O2 | 311.385 | 4 / 0 | 1.6 | Yes |
12551 | CHEMBL610918 | C18H20ClN3O | 329.828 | 3 / 1 | 4.1 | Yes |
464388 | CHEMBL3633978 | C21H21N3O2 | 347.418 | 3 / 0 | 3.0 | Yes |
12906 | VU 0361737 | C13H11ClN2O2 | 262.693 | 3 / 1 | 2.6 | Yes |
13007 | BDBM50201658 | C9H9ClN4O2S | 272.707 | 4 / 3 | 1.5 | Yes |
13015 | CHEMBL2349537 | C18H16F2N4O | 342.35 | 5 / 1 | 3.3 | Yes |
13082 | CHEMBL3122219 | C20H18N6O | 358.405 | 6 / 0 | 2.0 | Yes |
13323 | QUISQUALIC ACID | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
13331 | 2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid | C5H7N3O5 | 189.127 | 6 / 3 | -3.9 | Yes |
13423 | CHEMBL568515 | C15H17NO2S | 275.366 | 4 / 1 | 4.6 | Yes |
13460 | CHEMBL215746 | C15H12N2O | 236.274 | 2 / 1 | 2.7 | Yes |
13557 | CHEMBL1289784 | C19H22Cl2N2O | 365.298 | 3 / 0 | 4.5 | Yes |
13571 | CHEMBL511355 | C18H22N4O2 | 326.4 | 4 / 0 | 2.4 | Yes |
13791 | CHEMBL407707 | C18H14F3N3O2S | 393.384 | 7 / 1 | 3.7 | Yes |
13879 | CHEMBL363062 | C22H16ClN3O | 373.84 | 2 / 1 | 5.3 | No |
14196 | CHEMBL235975 | C18H14N4O2S | 350.396 | 6 / 1 | 3.2 | Yes |
14395 | CHEMBL1630064 | C14H13FN4O3 | 304.281 | 6 / 1 | 2.2 | Yes |
14890 | CHEMBL362217 | C16H11N3S | 277.345 | 4 / 0 | 3.0 | Yes |
14913 | CHEMBL1771621 | C19H23N3O2 | 325.412 | 4 / 0 | 3.2 | Yes |
14914 | CHEMBL1771622 | C19H23N3O2 | 325.412 | 4 / 0 | 3.2 | Yes |
555541 | 2Me4CPG | C10H11NO4 | 209.201 | 5 / 3 | -1.8 | Yes |
15055 | CHEMBL1257504 | C19H16N4O | 316.364 | 5 / 0 | 2.8 | Yes |
15216 | CHEMBL2334981 | C24H26ClN5OS | 468.016 | 5 / 2 | N/A | N/A |
15316 | CHEMBL1779862 | C19H17ClN2O | 324.808 | 2 / 0 | 3.9 | Yes |
15349 | CHEMBL388087 | C18H16N4OS | 336.413 | 5 / 0 | 3.1 | Yes |
442253 | CHEMBL3422865 | C22H21N5O2S | 419.503 | 5 / 2 | 3.9 | Yes |
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