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GPCR

NameOrexin receptor type 2
SpeciesRattus norvegicus (Rat)
GeneHcrtr2
Synonymhypocretin receptor 2
Hypocretin receptor type 2
hypocretin (orexin) receptor 2
orexin receptor type 2
Ox-2-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
UniProtP56719
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1275216
IUPHAR322
DrugBankN/A

Known ligands

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Total entries: 65
Page:  / 1 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
28982D structureDORA-22C23H22F2N4O2424.4527 / 03.6Yes
185202D structureSCHEMBL1717163C21H22FN3O2367.4244 / 13.7Yes
407372D structureOrexin receptor antagonist 10C19H18N6O2S394.4537 / 03.0Yes
560242D structureOrexin receptor antagonist 31C21H19N5O2S405.4767 / 03.0Yes
590622D structureOrexin receptor antagonist 17C21H21N7O3419.4458 / 02.6Yes
701332D structureOrexin receptor antagonist 34C23H20FN5O2417.4447 / 03.1Yes
726682D structureOrexin receptor antagonist 3C22H21N5O3403.4427 / 03.3Yes
5378472D structureCHEMBL3973097C21H17F2N5O2409.3977 / 13.3Yes
832162D structureOrexin receptor antagonist 1C21H20N6O2388.4316 / 03.0Yes
894542D structureSCHEMBL1716434C24H25FN4O2420.4886 / 03.5Yes
931462D structureOrexin receptor antagonist 6C21H19FN6O2406.4217 / 03.1Yes
4745532D structureCHEMBL3586442C21H22ClN7O423.9056 / 03.3Yes
1024972D structureSCHEMBL1717157C22H22FN5O4439.4478 / 13.1Yes
1025182D structureOrexin receptor antagonist 4C22H22N6O2402.4586 / 03.4Yes
1027342D structureSCHEMBL1716836C21H22ClN5O2411.895 / 04.1Yes
1031912D structureSCHEMBL1718116C21H22FN5O2395.4386 / 03.6Yes
1100932D structureOrexin receptor antagonist 14C19H18N6O2S394.4537 / 03.0Yes
5492482D structureCHEMBL3955752C22H18F2N4O2408.4096 / 04.4Yes
1250582D structureOrexin receptor antagonist 9C22H22N6O2402.4586 / 03.4Yes
1253152D structureSCHEMBL1716942C25H26FN3O2419.55 / 04.5Yes
5539222D structureACT 335827C31H38N2O5518.6546 / 15.5No
1278282D structureSCHEMBL1717515C23H25FN4O2408.4775 / 13.9Yes
4796932D structureCHEMBL3586434C21H22FN7O407.4537 / 02.8Yes
4812872D structureCHEMBL3586441C22H25N7O2419.4897 / 02.6Yes
1636672D structureSCHEMBL1716852C22H23FN4O2394.455 / 03.6Yes
1706852D structureEMPAC23H26N4O4S454.5457 / 02.5Yes
1708182D structureOrexin receptor antagonist 35C23H20FN5O2417.4447 / 03.1Yes
4856792D structureCHEMBL3586432C21H23N7O389.4636 / 02.7Yes
1976412D structureOrexin receptor antagonist 33C23H20FN5O2417.4447 / 03.1Yes
4876492D structureCHEMBL3586440C22H25N7O403.496 / 03.0Yes
4877102D structureCHEMBL3586426C23H24N4OS404.5325 / 04.0Yes
2092522D structureOrexin receptor antagonist 2C23H21N5O2399.4546 / 03.0Yes
2183662D structureSCHEMBL1717126C24H23FN4O4450.478 / 13.1Yes
2234412D structureSCHEMBL1717503C23H23FN4O2406.4616 / 03.5Yes
2288652D structureFILOREXANTC24H25FN4O2420.4886 / 03.9Yes
2312942D structureSCHEMBL1716701C24H25FN4O3436.4877 / 12.6Yes
4920772D structureCHEMBL3586437C21H23N7O389.4636 / 12.4Yes
2531612D structureSCHEMBL1717179C23H22F2N4O2424.4527 / 03.6Yes
2581572D structureOrexin receptor antagonist 36C23H20FN5O2417.4447 / 03.1Yes
2591862D structureSCHEMBL1716476C21H21F2N5O2413.4297 / 03.7Yes
2720552D structureOrexin receptor antagonist 20C22H24N4O3392.4596 / 02.8Yes
2732332D structureOrexin receptor antagonist 5C22H22N6O2402.4586 / 03.4Yes
2778902D structureSCHEMBL1717023C21H25FN2O3372.445 / 03.9Yes
2911712D structureSCHEMBL1716967C22H25N5O2391.4755 / 03.9Yes
2923482D structureCHEMBL3655663C21H22FN5O2395.4386 / 03.5Yes
5002742D structureCHEMBL3586433C21H22FN7O407.4537 / 02.8Yes
3138822D structureSCHEMBL1716975C22H24FN5O3425.4647 / 12.7Yes
5025122D structureUNII-AIS8N3O50BC21H22FN7O407.4537 / 02.8Yes
5548602D structureSeltorexantC21H22FN7O407.4537 / 02.8Yes
3214562D structureSCHEMBL1717368C24H24FN3O2405.4735 / 04.5Yes
3249362D structureSCHEMBL1716390C22H24FN5O2409.4656 / 03.9Yes
3315102D structureOrexin receptor antagonist 22C21H19FN6O2406.4217 / 03.1Yes
3336992D structureSCHEMBL1716517C26H27FN2O2418.5124 / 05.6No
3369092D structureSCHEMBL1716725C23H24FN3O2S425.5226 / 04.6Yes
3485002D structureOrexin receptor antagonist 30C20H19N7O2389.4197 / 02.9Yes
5454872D structureCHEMBL3394848C23H19F2N5O2435.4357 / 04.5Yes
3583362D structureSCHEMBL1716924C21H22BrN5O2456.3445 / 04.2Yes
3629502D structureOrexin receptor antagonist 15C21H19BrN6O2467.3276 / 03.7Yes
4560802D structureMK-3697C23H21N5O3S447.5138 / 12.5Yes
3702362D structureOrexin receptor antagonist, 7C21H19ClN6O2422.8736 / 03.6Yes
4566962D structureSCHEMBL9977884C21H20FN7O405.4376 / 02.4Yes
3868212D structureOrexin receptor antagonist 8C21H19FN6O2406.4217 / 03.1Yes
3961862D structureOrexin receptor antagonist 32C21H19N5O2S405.4767 / 02.7Yes
5331022D structureCHEMBL3741194C25H26N2O5S466.5527 / 05.1No
4302892D structureSB-649868C26H24FN3O3S477.5546 / 15.2No

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