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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesMus musculus (Mouse)
GeneChrm2
Synonymcholinergic receptor
cholinergic receptor, muscarinic 2
AChR M2
Chrm-2
M2 muscarinic acetylcholine receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGGTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDDNSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtQ9ERZ4
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3197
IUPHAR14
DrugBankN/A

Known ligands

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Total entries: 47
Page:  / 1 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
66092D structurecarbacholC6H15ClN2O2182.6483 / 1N/AN/A
127222D structureN,N'-Bis[2-[[5-(dimethylaminomethyl)-2-furanyl]methylthio]ethyl]-1-nitroethene-1,2-diamineC22H35N5O4S2497.67310 / 22.7Yes
227512D structureBRN 5352858C18H28N2O2S2368.5546 / 02.5Yes
257252D structure114724-56-0C9H13N3O179.2234 / 00.8Yes
258672D structureBRN 5360513C24H32N2O2S2444.6526 / 03.8Yes
285092D structureCHEMBL542404C9H15ClN2O3234.684 / 1N/AN/A
324452D structureCHEMBL552656C12H21ClN2O3276.7614 / 1N/AN/A
343502D structureCHEMBL553727C14H24ClN3O4333.8136 / 1N/AN/A
370292D structureCHEMBL538467C6H11ClN2O2178.6163 / 2N/AN/A
373582D structureCHEMBL74823C14H15ClN2O3294.7354 / 02.3Yes
428222D structureBRN 5358078C24H40N2O2S2452.7166 / 05.0Yes
440492D structureCHEMBL553865C12H21ClN2O2S292.8224 / 1N/AN/A
567272D structureBRN 5356180C21H34N2O2S2410.6356 / 03.5Yes
613152D structureCHEMBL540543C16H21ClN2O3324.8054 / 1N/AN/A
778942D structureCHEMBL75380C10H16N2O2S228.314 / 01.1Yes
976812D structureCHEMBL554011C13H21ClN2O5320.776 / 1N/AN/A
1070352D structureBRN 5834442C16H20N4O5S380.4198 / 13.2Yes
1097972D structureBRN 5836042C16H21N5O5S395.4349 / 23.1Yes
1158152D structureCHEMBL75045C14H16N2O2S276.3544 / 02.3Yes
1164312D structurearecolineC8H13NO2155.1973 / 00.3Yes
1189862D structureCHEMBL542406C10H17ClN2O3248.7074 / 1N/AN/A
1316472D structureCHEMBL542879C20H23Cl2N3O5456.326 / 2N/AN/A
1449192D structureCHEMBL542886C8H13ClN2O3220.6534 / 2N/AN/A
1486822D structureBDBM50005504C22H35N5O4S2497.67310 / 11.9Yes
1568312D structureCHEMBL76063C11H16N2O5256.2586 / 00.0Yes
1934812D structureBRN 5365697C22H34N6O2S2478.6748 / 21.8Yes
1970532D structureCHEMBL553520C10H17ClN2O3248.7074 / 1N/AN/A
2068352D structureCHEMBL543832C14H23ClN2O5334.7976 / 1N/AN/A
2174652D structureBRN 5359326C25H42N2O2S2466.7436 / 05.5No
2286612D structureBRN 5357514C23H38N2O2S2438.6896 / 04.4Yes
2516232D structureBRN 5369860C26H36N6O6S2592.7312 / 24.9No
2605472D structurephysostigmineC15H21N3O2275.3524 / 10.7Yes
2610242D structureBRN 5837136C16H22N6O5S410.44910 / 33.0Yes
2812812D structureBRN 5354948C20H32N2O2S2396.6086 / 03.2Yes
2986262D structureRS-86C11H19BrN2O2291.1893 / 1N/AN/A
3028772D structureCHEMBL544767C9H15ClN2O3234.684 / 1N/AN/A
3037572D structureOxotremorineC12H18N2O206.2892 / 00.4Yes
3064432D structureBRN 5363156C30H36N2O2S2520.756 / 05.4No
3243902D structureCHEMBL555730C9H15ClN2O3234.684 / 2N/AN/A
3596402D structureSCHEMBL8307259C9H11F3N4O3280.2079 / 2N/AN/A
3609462D structureCarbamylcholineC6H15N2O2+147.1982 / 1-0.4Yes
3685672D structureCHEMBL553123C8H13ClN2O2S236.7144 / 2N/AN/A
3823532D structureCHEMBL419451C11H16N2O3224.264 / 00.7Yes
4010422D structureCHEMBL306839C10H15N3O4241.2475 / 1-1.0Yes
4130022D structureTacrineC13H14N2198.2692 / 12.7Yes
4354952D structureBRN 5356615C22H36N2O2S2424.6626 / 03.9Yes
4405562D structureBRN 5353847C19H30N2O2S2382.5816 / 02.8Yes

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