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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	donepezil
Molecular formula	C24H29NO3
IUPAC name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Molecular weight	379.5
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.3
Synonyms	donepezilo 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)- HSDB 7743 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one KBioSS_002144 32288-EP2281815A1 Q-100098 32288-EP2298772A1 ST2409236 32288-EP2311827A1 AB1004836 Aricept ODT C24H29NO3 E2020 2,3-dihydro-5,6-dimethoxy-2[[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one I903 32288-EP2269989A1 MolPort-003-847-014 32288-EP2289886A1 SC-19032 32288-EP2305640A2 Z1741977105 AB0013927 ADEBPBSSDYVVLD-UHFFFAOYSA-N BCP9000622 CHEMBL502 Donaz (TN) (RS)-2-[(1-BENZYL-PIPERIDIN-4-YL)METHYL]-5,6-DIMETHOXYINDAN-1-ONE 120014-06-4 FT-0601545 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one KBio2_004712 32288-EP2278970A1 Oprea1_188452 32288-EP2298759A1 Spectrum5_001662 32288-EP2308839A1 AB00640013_09 AN-9524 BR-72906 D07869 Donepezil (transdermal patch, Alzheimer's disease) donepezilum 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]- HY-14566 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one KS-00000KZG 32288-EP2283811A1 S-6065 32288-EP2298776A1 STK003905 5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one AC-6969 BC204600 CHEBI:53289 DB00843 014D064 EBD50998 2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one KB-67912 32288-EP2269990A1 MRF-0000323 32288-EP2295417A1 SCHEMBL2149 32288-EP2305664A1 AB00640013-07 AK-72906 BCPP000253 CS-2866 142057-79-2 GTPL6599 2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-indan-1-one KBio2_007280 32288-EP2280010A2 PubChem22271 32288-EP2298761A1 Spectrum_001664 32288-EP2311823A1 AB00640013_10 Aricept BRD-A49160188-003-04-4 D0NS6H Donepezil [INN:BAN] DTXSID8048317 2,3-dihydro-5,6-dimethoxy-2 [[1-(phenyl methyl)-4-piperidinyl]methyl]-1H-inden-1-one I06-0343 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one LS-81819 32288-EP2289882A1 SBI-0206789.P001 32288-EP2301933A1 TL8000531 AC1L1FAE BCP07590 Domepezil (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine; Donepezil Eranz 2-[(1-benzyl-4-piperidyl)methyl]- 5,6-dimethoxy-2,3-dihydroinden-1-one KBio2_002144 32288-EP2275420A1 NCGC00167537-01 32288-EP2298758A1 SCHEMBL8265876 32288-EP2305675A1 AB00640013-08 AKOS000277311 BDBM8960 CTK4C2920 Donepezil (INN) [ Show all ]
Inchi Key	ADEBPBSSDYVVLD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
PubChem CID	3152
ChEMBL	CHEMBL502
IUPHAR	N/A
BindingDB	8960
DrugBank	DB00843
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
2162	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
2161	Histamine H3 receptor	Q9Y5N1	HRH3	Homo sapiens (Human)	445

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