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Ligand

NameRY-764
Molecular formulaC34H51FN4O3
IUPAC name(1R,4S,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide
Molecular weight582.805
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.4
SynonymsGTPL1337
SCHEMBL14040521
Anti-obesity therapy, Merck &Co
Melanocortin agonists (obesity/erectile dysfunction), Merck & Co
(1R,4S,6R)-N-[(2R)-1-[4-(tert-butylcarbamoyl)-4-cyclohexylpiperidin-1-yl]-3-(4-fluorophenyl)-1-oxopropan-2-yl]-7-methyl-7-azabicyclo[2.2.2]octane-6-carboxamide
[ Show all ]
Inchi KeyARFBDECCXOFCBN-HOLBEBDISA-N
Inchi IDInChI=1S/C34H51FN4O3/c1-33(2,3)37-32(42)34(25-8-6-5-7-9-25)16-18-39(19-17-34)31(41)28(21-23-10-13-26(35)14-11-23)36-30(40)27-20-24-12-15-29(27)38(4)22-24/h10-11,13-14,24-25,27-29H,5-9,12,15-22H2,1-4H3,(H,36,40)(H,37,42)/t24-,27+,28+,29+/m0/s1
PubChem CID6918851
ChEMBLCHEMBL364346
IUPHAR1337
BindingDB50169442
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Known GPCRs

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Total entries: 7
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
12401Adrenocorticotropic hormone receptorQ01718MC2RHomo sapiens (Human)297
12400Melanocortin receptor 3P41968MC3RHomo sapiens (Human)323
12396Melanocortin receptor 4P56450Mc4rMus musculus (Mouse)332
12397Melanocortin receptor 4P32245MC4RHomo sapiens (Human)332
12399Melanocortin receptor 4P70596Mc4rRattus norvegicus (Rat)332
12398Melanocortin receptor 5P33032MC5RHomo sapiens (Human)325
12402Melanocyte-stimulating hormone receptorQ01726MC1RHomo sapiens (Human)317

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