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Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
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Ligand

Name	Yohimbine
Molecular formula	C21H26N2O3
IUPAC name	methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Molecular weight	354.45
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.9
Synonyms	Yohimbe bark extract D08685 Yohimbol-16alpha-carboxylic acid, methyl ester (6CI) DTXSID9040130 HMS2234C18 (+)-Yohimbine KBio3_001031 17a-hydroxy-16a-methoxycarbonyl-yohimbane methyl (1S,15R,18S,19R,20S)-18-hydroxy-3,13-diazapentacyclo[11.8.0.0;{2,10}.0;{4,9}.0;{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate 65Y190 NCGC00025018-05 Aphrosol Prestwick2_000584 Bio1_000944 SPBio_002647 BRD-K35586044-003-11-3 Yocon CHEBI:10093 Yohimbic acid methyl ester Yovital GTPL102 IDI1_002213 (1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2'',3'':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester hydrochloride KBioSS_000576 2Y49VWD90Q methyl hydroxy[?]carboxylate AKOS015902024 NCGC00025018-10 BCBcMAP01_000032 Quebrachine Bio2_000938 Thybine BSPBio_001236 Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy-, methyl ester CHEMBL537669 Corynine Yohimbine (DCF) DSSTox_GSID_40130 HMS1990N17 KBio2_003144 17-Hydroxy-yohimbane-16-carboxylic acid methyl ester MCULE-1043513122 MRF-0000020 APHRODINE Prestwick0_000584 Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv. SMP1_000320 BRD-K35586044-001-02-6 trans-Quinolizidine yohimbine CCG-205284 Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-(9CI) Yohimbe Extract Yohimbine D0H4JM Yohimex EINECS 205-672-0 HY-12715 (16alpha,17alpha)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester KBio3_001032 17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester methyl (1S,15R,18S,19R,20S)-18-hydroxy-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8-tetraene-19-carboxylate AC1L1S1D NCGC00025018-06 API0006398 Prestwick3_000584 Bio1_001433 SR-01000075297 BRN 0097276 Yohimar Yohimbin DB01392 ZINC3860825 HMS1362N17 Johimbin Lopac0_001210 37247-87-3 MLS000728591 Amberlite CG-400 NCGC00025018-11 BDBM50013515 SC-25096 BLGXFZZNTVWLAY-SCYLSFHTSA-N Tox21_110019 C09256 Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)- cid_6169 CS-5173 YOHIMBINE CHLORIDE DSSTox_RID_79446 HMS2089G19 (+)-Yohimbin KBio2_005712 17-Hydroxyyohimban-16-carboxylic acid methyl ester methyl (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylate NCGC00013260-01 Aphrodyne Prestwick1_000584 Bio1_000455 SMR000470778 BRD-K35586044-003-03-0 UNII-2Y49VWD90Q CCRIS 9415 Yohimban-16alpha-carboxylic acid, 17alpha-hydroxy-, methyl ester (8CI) YOHIMBE HYDROCHLORIDE Dayto himbin Yoman GS-5751 I14-13374 (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester KBioGR_000576 2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester methyl 17alpha-hydroxyyohimban-16alpha-carboxylate Actibine NCGC00025018-07 Baron-X Quebrachin Bio2_000458 SR-01000075297-5 BSPBio_000428 Yohimban-16-.alpha.-carboxylic acid, 17-.alpha.-hydroxy-, methyl ester CHEMBL15245 cid_8969 DSSTox_CID_20130 HMS1792N17 KBio2_000576 146-48-5 LS-162738 4-25-00-01237 (Beilstein Handbook Reference) MolPort-001-794-653 AN-23279 NSC19509 BDBM50203564 SCHEMBL33954 BPBio1_000472 Tox21_110019_1 CAS-146-48-5 Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)- (9CI) [ Show all ]
Inchi Key	BLGXFZZNTVWLAY-SCYLSFHTSA-N
Inchi ID	InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
PubChem CID	8969
ChEMBL	CHEMBL15245
IUPHAR	102
BindingDB	50013515, 50203564
DrugBank	DB01392
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
26585	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
26596	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
26579	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
26593	5-hydroxytryptamine receptor 1B	P28564	Htr1b	Rattus norvegicus (Rat)	386
26595	5-hydroxytryptamine receptor 1B	P28334	Htr1b	Mus musculus (Mouse)	386
26618	5-hydroxytryptamine receptor 1B	O08892	HTR1B	Cavia porcellus (Guinea pig)	389
26575	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
26600	5-hydroxytryptamine receptor 1D	P28565	Htr1d	Rattus norvegicus (Rat)	374
26606	5-hydroxytryptamine receptor 1D	P11614	HTR1D	Canis lupus familiaris (Dog)	377
26583	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
26576	5-hydroxytryptamine receptor 1F	P30940	Htr1f	Rattus norvegicus (Rat)	366
26609	5-hydroxytryptamine receptor 1F	P30939	HTR1F	Homo sapiens (Human)	366
26626	5-hydroxytryptamine receptor 1F	Q02284	Htr1f	Mus musculus (Mouse)	366
26574	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
26602	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
26572	5-hydroxytryptamine receptor 2B	P30994	Htr2b	Rattus norvegicus (Rat)	479
26584	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
26580	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
26591	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
26605	5-hydroxytryptamine receptor 2C	P34968	Htr2c	Mus musculus (Mouse)	459