Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Etorphine
Molecular formula	C25H33NO4
IUPAC name	19-(2-hydroxypentan-2-yl)-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,16-tetraen-11-ol
Molecular weight	411.542
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.1
Synonyms	6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-.alpha.,17-dimethyl-.alpha.-propyl-, [5.alpha.,7.alpha.(R)]- CAHCBJPUTCKATP-UHFFFAOYSA-N M99 7-.alpha.-(1-(R)-Hydroxy-1-methylbutyl)-6,14-endo-ethenotetrahydrooripavine SCHEMBL10031275 6,14-endo-Ethenotetrahydrooripavine, 7.alpha.-((R)-1-hydroxy-1-methylbutyl)- AC1LARGT GTPL1625 [5.alpha.,7.alpha.(R)]-4,5-Epoxy-3-hydroxy-6-methoxy-.alpha.,17-dimethyl-.alpha.-propyl-6,14-ethenomorphinan-7-methanol 6,7,8,14-Tetrahydro-7.alpha.-(1-hydroxy-1-methylbutyl)-6,14-endo-ethenooripavine CAS_61677 NSC_61677 7.alpha.-Etorphine ETORPHINE - HCI Tetrahydro-7-.alpha.-(1-hydroxy-1-methylbutyl)-6,14-endo-ethenooripavine 6,14-endo-Ethenotetrahydrooripavine, 7.alpha.-(1-hydroxy-1-methylbutyl)- BDBM82425 L024016 7,8-Dihydro-7-.alpha.-(1-(R)-hydroxy-1-methylbutyl)-O(sup 6)-methyl-6,14-endo-ethenomorphine D04JCK Oripavine, 6,14-endo-ethylenetetrahydro-7-(1-hydroxy-1-methylbutyl)- 19-Propylorvinol FT-0668440 Tetrahydro-7-.alpha.-(2-hydroxy-2-pentyl)-6,14-endo-ethenooripavine [ Show all ]
Inchi Key	CAHCBJPUTCKATP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3
PubChem CID	518962
ChEMBL	N/A
IUPHAR	1625
BindingDB	82425
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
37182	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
459551	Delta-type opioid receptor	P79291	OPRD1	Sus scrofa (Pig)	228
37181	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
37183	Kappa-type opioid receptor	P41144	OPRK1	Cavia porcellus (Guinea pig)	380
37184	Mu-type opioid receptor	P97266	OPRM1	Cavia porcellus (Guinea pig)	98
37185	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
553435	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218