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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Spiramide
Molecular formula	C22H26FN3O2
IUPAC name	8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Molecular weight	383.467
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.4
Synonyms	AMI-193 BPBio1_001259 D0V5SQ Fluroxyspiramine NCGC00024633-05 Spiramide [INN] UNII-471LF4O004 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(3-(4-fluorophenoxy)propyl)-1-phenyl- 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone BDBM86525 CAS_77445 DSSTox_RID_80051 MolPort-003-983-510 NSC_77445 SR-01000597677 ACM510747 BN0070 CHEMBL79834 Espiramida [INN-Spanish] NCGC00024633-03 SCHEMBL2110721 Tox21_110914 510-74-7 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one API0006556 BRD-K94512704-001-02-1 DSSTox_CID_22579 GTPL175 NCGC00024633-06 Spiramidum ZINC1846593 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl- AC1L2981 Biomol-NT_000039 CHEBI:64207 DTXSID6042579 NCGC00024633-01 R 5808 SR-01000597677-1 3824-91-7 (mono-hydrochloride salt) AKOS024458544 BPBio1_001087 CTK8F7702 FJUKDAZEABGEIH-UHFFFAOYSA-N NCGC00024633-04 Tox21_110914_1 8-(3-(4-Fluorophenoxy)propyl)-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one 8-[3-(4-fluorophenoxy)propyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one B6335 CAS-510-74-7 DSSTox_GSID_42579 L023992 NCGC00024633-07 Spiramidum [INN-Latin] 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[3-(p-fluorophenoxy)propyl]-1-phenyl- AC1Q4ONW Biomol-NT_000087 Espiramida NCGC00024633-02 R-5808 Tocris-0524 471LF4O004 [ Show all ]
Inchi Key	FJUKDAZEABGEIH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26FN3O2/c23-18-7-9-20(10-8-18)28-16-4-13-25-14-11-22(12-15-25)21(27)24-17-26(22)19-5-2-1-3-6-19/h1-3,5-10H,4,11-17H2,(H,24,27)
PubChem CID	68186
ChEMBL	CHEMBL79834
IUPHAR	175
BindingDB	86525
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
80079	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
80075	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
80074	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
80077	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
80080	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
80078	D(1A) dopamine receptor	Q61616	Drd1	Mus musculus (Mouse)	446
80076	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443

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