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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	PAPP
Molecular formula	C19H22F3N3
IUPAC name	4-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]aniline
Molecular weight	349.401
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.0
Synonyms	4-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)aniline Biomol-NT_000160 CTK8D5097 J-011585 LY-165,163, solid NCGC00015907-04 p-Aminophenethyl-m-trifluoromethylphenyl piperazine SR-01000075576-1 ZINC1619831 8HAJ699EWG C19H22F3N3 EU-0101132 LP01132 MFCD00055098 NCGC00094399-02 PAPP (LY-165,163) SELECTIVE 5-HT1A SERO AKOS030547154 HMS3263D05 LY 165163 NCGC00015907-02 NCI60_009079 SMR000326833 4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine BPBio1_000375 D0T4PS Lopac-S-009 LY-165,163; p-Aminophenethyl-m-trifluoromethylphenyl piperazine NCGC00015907-05 p-NH2-PE-Tfmpp Tox21_501132 AC1L3TO7 CCG-205206 GTPL18 LS-173712 MLS000859974 NCGC00094399-03 S-009 1814-64-8 Benzenamine, 4-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)- CHEMBL1256693 HMS3369D03 LY-165,163 NCGC00015907-03 NSC628235 SR-01000075576 UNII-8HAJ699EWG 4-[2-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]aniline BRD-K14282469-001-01-5 DTXSID30171136 Lopac0_001132 LY-165163 NCGC00094399-01 1-(2-(4-Aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine AC1Q4K3D CHEBI:92250 HMS2232I03 LY 165,163 NCGC00015907-01 NCGC00261817-01 SCHEMBL3976547 [ Show all ]
Inchi Key	GAAKALASJNGQKD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2
PubChem CID	121930
ChEMBL	CHEMBL1256693
IUPHAR	18
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
553712	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
553713	5-hydroxytryptamine receptor 6	P31388	Htr6	Rattus norvegicus (Rat)	436
91404	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
91400	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
91399	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
91402	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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