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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL377874
Molecular formula	C35H32Cl2N4
IUPAC name	3-[4-[1-(1-benzylpiperidin-4-yl)-3-(4,6-dichloro-1H-benzimidazol-2-yl)propyl]phenyl]benzonitrile
Molecular weight	579.569
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	8.8
Synonyms	4''-[1-(1-benzyl-piperidin-4-yl)-3-(4,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-biphenyl-3-carbonitrile BDBM50186800 SCHEMBL12561197 4''-[1-(1-benzyl-piperidin-4-yl)-3-(5,7-dichloro-1H-benzoimidazol-2-yl)-propyl]-biphenyl-3-carbonitrile
Inchi Key	GAWJZFWFWAJWRF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H32Cl2N4/c36-30-20-32(37)35-33(21-30)39-34(40-35)14-13-31(28-15-17-41(18-16-28)23-24-5-2-1-3-6-24)27-11-9-26(10-12-27)29-8-4-7-25(19-29)22-38/h1-12,19-21,28,31H,13-18,23H2,(H,39,40)
PubChem CID	11433168
ChEMBL	CHEMBL377874
IUPHAR	N/A
BindingDB	50186800
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
91975	Melanin-concentrating hormone receptor 1	Q99705	MCHR1	Homo sapiens (Human)	422
91974	Melanin-concentrating hormone receptor 2	Q969V1	MCHR2	Homo sapiens (Human)	340

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