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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	latanoprost
Molecular formula	C26H40O5
IUPAC name	propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Molecular weight	432.601
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	4.3
Synonyms	Latanoprost, (+/-)- NC00196 propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(3R)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoate 130209-82-4 SR-01000759428-4 XA-41 AKOS024458331 DTXSID1041057 HY-B0577 Jsp001835 L1167_SIGMA latanoprostum PhXA 41 (15R)-Latanoprost SAM001246671 209L824 TL8000716 AB00640005-04 Xalatan (TN) BDBM50240648 CS-2758 GGXICVAJURFBLW-CEYXHVGTSA-N Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate Latanoprost (JAN/USAN/INN) MLS001424106 PhXA41 (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid propan-2-yl ester SMR000466354 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-, 1-methylethyl ester UNII-8S5FB3XXG8 component GGXICVAJURFBLW-CEYXHVGTSA-N ABP001061 CCG-100946 HMS2089J17 Isopropyl-(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate Latanoprost, >=98% (HPLC), oil NCGC00246969-01 propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate 155551-81-8 ST24047444 6Z5B6HVF6O XA41 AR-202 CHEMBL1051 EX-A1770 Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate L-PPDS MFCD00216074 PHXA-41 (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptanoic acid 1-methylethyl ester SC-18987 33537-EP2295409A1 Tris(2,4-dimethylphenyl)phosphine-5,5',5""""-trisulfonic acid trisodium salt AB00640005-06 ZINC12468792 C26H40O5 D00356 GTPL1961 Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate Latanoprost [USAN:INN:BAN] MolPort-003-942-862 propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate (Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate SR-01000759428 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-, 1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R*),3-alpha,5-alpha))- XA 41 AC1NSK8Q CHEBI:6384 DB00654 HMS3715N22 J-005764 Latanoprost, United States Pharmacopeia (USP) Reference Standard Nova-21027 s4709 T-2345 A806039 Xalatan AT-3016 CPD000466354 GAAP Ofteno isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate L0262 latanoprost (isopropyl ester) MLS000759468 PhXA34 [as 15(R,S)-isomer] (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester SCHEMBL24698 33537-EP2311820A1 UNII-6Z5B6HVF6O AB2000019 Catioprost D0C6NM HMS2051H11 Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate [ Show all ]
Inchi Key	GGXICVAJURFBLW-CEYXHVGTSA-N
Inchi ID	InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
PubChem CID	5311221
ChEMBL	CHEMBL1051
IUPHAR	1961
BindingDB	50240648
DrugBank	DB00654
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
96121	Beta-2 adrenergic receptor	P07550	ADRB2	Homo sapiens (Human)	413
96124	Prostacyclin receptor	P43119	PTGIR	Homo sapiens (Human)	386
460074	Prostaglandin E2 receptor EP1 subtype	P34995	PTGER1	Homo sapiens (Human)	402
96123	Prostaglandin E2 receptor EP2 subtype	P43116	PTGER2	Homo sapiens (Human)	358
460073	Prostaglandin E2 receptor EP3 subtype	P43115	PTGER3	Homo sapiens (Human)	390
460072	Prostaglandin E2 receptor EP4 subtype	P35408	PTGER4	Homo sapiens (Human)	488
96122	Prostaglandin F2-alpha receptor	P43088	PTGFR	Homo sapiens (Human)	359

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