Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	kynurenic acid
Molecular formula	C10H7NO3
IUPAC name	4-oxo-1H-quinoline-2-carboxylic acid
Molecular weight	189.17
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.3
Synonyms	KB-53045 4-Hydroxyquinoline-2-carboxylic acid Kinurenic acid Kynuronic acid AKOS000118368 MolPort-000-881-826 BBL027606 NCGC00015581-07 CAS_492-27-3 NCGC00024505-06 CTK0H6756 Oprea1_032085 DTXSID8075417 H030S2S85J 2-Quinolinecarboxylic acid, 4-hydroxy- HMS500P11 4-hydroxy-Quinaldate SC-50442 Spectrum4_000814 ST24043960 UX00002048 4-Hydroxyquinaldate KBio2_004164 4-oxo-1,4-dihydroquinoline-2-carboxylic acid KYNA AC1L1GUE LP00716 AN-45278 NCGC00015581-02 bmse000410 NCGC00024505-01 CH-565 NINDS_000309 DB-008408 PubChem7255 EU-0100716 HMS1736A10 I14-11091 R1152 SMR000112310 SR-01000075455 Tocris-0223 Z94602408 J-006786 4-Hydroxyquinaldinic acid KBioGR_001327 593D947 Kynurenic acid, >=98% AJ-72562 MFCD00006753 B6227 NCGC00015581-05 C01717 NCGC00024505-04 CHEMBL299155 NSC58973 DB11937 Quinaldic acid, 4-hydroxy- (8CI) GS-3763 13593-94-7 HMS3262O13 4-Hydroxy-2-quinolincarboxylic acid SBB003671 Spectrum2_001342 ST036704 Transtorine KBio1_000309 4-hydroxyquinolinium-2-carboxylate KS-00000G3H AB0025093 Lopac-K-3375 AKOS000277721 MolPort-002-469-388 BDBM81975 NCGC00015581-08 CCG-39280 NCGC00024505-07 CTK1D7115 PDSP1_000132 EINECS 207-751-5 HCZHHEIFKROPDY-UHFFFAOYSA- 2-Quinolinecarboxylicacid, 1,4-dihydro-4-oxo- HY-100806 4-hydroxy-Quinaldic acid SCHEMBL22979 Spectrum5_001318 STL294769 W6496 4-Hydroxyquinaldic acid KBio2_006732 4-oxo-1H-quinoline-2-carboxylic acid Kynurenate AC1Q72XZ LS-141641 ANW-45658 NCGC00015581-03 BPBio1_001350 NCGC00024505-02 CHEBI:18344 NSC 58973 DB-081634 QC-8403 FT-0618747 HMS1921C20 4-HYDROXQUINOLINE-2-CARBOXYLIC ACID/KYNURENIC ACID IDI1_000309 RTR-017779 SPBio_001523 SR-01000075455-1 Tox21_500716 ZINC8584773 K 3375 4-hydroxyquinoline-2-carboxylate KBioSS_001596 6F535706-B297-4930-A3FC-7A2823830118 Kynurensaeure AK-26023 MLS002172436 BB 0262293 NCGC00015581-06 C10H7NO3 NCGC00024505-05 CS-W020664 NSC_5280455 DivK1c_000309 Quinurenic acid GTPL2918 2-Carboxy-4-hydroxyquinoline HMS3266C13 4-Hydroxy-2-quinolinecarboxylic acid SC-20062 Spectrum3_001390 ST066912 UNII-H030S2S85J 4-Hydroxy-quinoline-2-carboxylic acid KBio2_001596 4-Oxo-1,4-dihydro-quinoline-2-carboxylic acid KYA AB0097231 Lopac0_000716 ALBB-014130 NCGC00015581-01 Biomol-NT_000229 NCGC00015581-09 CCRIS 4428 NCGC00261401-01 D01SHB PDSP2_000131 EN300-13998 HCZHHEIFKROPDY-UHFFFAOYSA-N 2-Quinolinecarboxylicacid, 4-hydroxy- I04-5756 Quinurenic acid\|Kynurenate SMP1_000172 Spectrum_001116 STL301826 Z-8492 4-Hydroxyquinaldinate KBio3_002200 492-27-3 AE-641/00585057 MCULE-4310803796 ANW-59277 NCGC00015581-04 BSPBio_002980 NCGC00024505-03 NSC-58973 Quinaldic acid, 4-hydroxy- FT-0683827 1,4-Dihydro-4-oxoquinoline-2-carboxylic acid HMS2269G22 4-Hydroxy-2-chinolincarbonsaeure InChI=1/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14) s4719 SPECTRUM1500688 SR-01000075455-3 TR-035381 [ Show all ]
Inchi Key	HCZHHEIFKROPDY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
PubChem CID	3845
ChEMBL	CHEMBL299155
IUPHAR	2918
BindingDB	81975
DrugBank	DB11937
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
111785	G-protein coupled receptor 35	Q9HC97	GPR35	Homo sapiens (Human)	309
553807	G-protein coupled receptor 35	Q9ES90	Gpr35	Mus musculus (Mouse)	307
111786	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218