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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	xylometazoline
Molecular formula	C16H24N2
IUPAC name	2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
Molecular weight	244.382
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.2
Synonyms	Xylometazoline (INN) CHEMBL312448 ZX-AL000401 Decongestant (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences HMS3604M22 KBioGR_000903 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro- MolPort-000-198-725 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline NCGC00016101-09 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole Prestwick0_000223 526B363 SPBio_000910 Ba-11391 stas BSPBio_002032 CAS-1218-35-5 Xylometazoline [INN:BAN] D08684 EINECS 208-390-6 KBio1_000158 L001171 1H-Imidazole,2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro- NCGC00016101-03 2-IMIDAZOLINE, 2-(4-tert-BUTYL-2,6-DIMETHYLBENZYL)- Novorin 2-{[4-(tert-butyl)-2,6-dimethylphenyl]methyl}-2-imidazoline Prestwick3_000223 AC1L1KYN Spectrum3_000586 BPBio1_000293 VU0239751-6 Xilometazolina [INN-Spanish] CHEBI:10082 Xylomethazoline FT-0603452 KBio2_005998 LS-79581 2-(4-tert-butyl-2,6-dimethyl-benzyl)-2-imidazoline;hydrochloride NCGC00016101-06 2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole Otrivine SCHEMBL34087 AN-45560 Spectrum_000382 BRN 0180524 C-14837 Xylometazoline (nasal mucoadhesive/MucoAd, congestion) cid_5282386 DivK1c_000158 HUCJFAOMUPXHDK-UHFFFAOYSA-N KBioSS_000862 1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro- (9CI) NCGC00016101-01 2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole NCGC00024281-03 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole;hydrochloride Prestwick1_000223 AB00053567_11 SPBio_002186 Balminil (TN) STK558658 CC-05925 Xylometazolinum D0Y4DY EN300-02385 KBio2_000862 Lopac-X-6000 2-(4'-tert-butyl-2',6'-dimethylphenylmethyl)imidazoline NCGC00016101-04 2-[(4-t-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole Otriven SBB038185 AC1Q2GWN Spectrum4_000382 BRD-K08356259-003-05-6 WPY40FTH8K ZINC57534 DB06694 GTPL517 KBio3_001532 1218-35-5 (mono-hydrochloride) MCULE-9501725536 2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole NCGC00016101-07 2-[(4-tert-butyl-2,6-dimethyl-phenyl)methyl]-4,5-dihydro-1H-imidazole;hydrochloride Otrix 526-36-3 SEL14934364 Ba 11391 ST024781 BSPBio_000265 C07913 Xylometazoline (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences CTK4J6214 DTXSID8046957 IDI1_000158 KS-5071 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro- NCGC00016101-02 2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole # NINDS_000158 2-[[4-(1,1-Dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole Prestwick2_000223 AB00053567_12 Spectrum2_000945 BDBM30703 UNII-WPY40FTH8K Xilometazolina CCG-205342 Xylometazolinum [INN-Latin] DB-052151 F1371-0282 KBio2_003430 Lopac0_001269 2-(4-(tert-butyl)-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole NCGC00016101-05 2-[(4-t-butyl-2,6-dimethylphenyl)methyl]4,5dihydro-1H-imidazole Otrivin 5-23-07-00109 (Beilstein Handbook Reference) SBI-0051235.P003 AKOS000115430 Spectrum5_001469 BRD-K08356259-003-15-5 [ Show all ]
Inchi Key	HUCJFAOMUPXHDK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)
PubChem CID	5709
ChEMBL	CHEMBL312448
IUPHAR	517
BindingDB	30703
DrugBank	DB06694
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
124171	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
124169	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
124172	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
124179	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
124173	Alpha-1A adrenergic receptor	P35348	ADRA1A	Homo sapiens (Human)	466
555969	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
124177	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
124178	Alpha-1D adrenergic receptor	P25100	ADRA1D	Homo sapiens (Human)	572
553914	Alpha-1D adrenergic receptor	P23944	Adra1d	Rattus norvegicus (Rat)	561
124168	Alpha-2A adrenergic receptor	Q01338	Adra2a	Mus musculus (Mouse)	450
124174	Alpha-2A adrenergic receptor	P08913	ADRA2A	Homo sapiens (Human)	450
124176	Alpha-2B adrenergic receptor	P18089	ADRA2B	Homo sapiens (Human)	450
124170	Alpha-2C adrenergic receptor	P18825	ADRA2C	Homo sapiens (Human)	462
124167	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
124181	Sphingosine 1-phosphate receptor 3	Q99500	S1PR3	Homo sapiens (Human)	378
124175	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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