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Ligand

NameNafadotride
Molecular formulaC22H27N3O2
IUPAC nameN-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide
Molecular weight365.477
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.0
SynonymsAKOS024257976
CPD000466292
HMS2232B11
LS-187623
4-Cyano-1-methoxy-naphthalene-2-carboxylic acid (1-butyl-pyrrolidin-2-ylmethyl)-amide
[ Show all ]
Inchi KeyIDZASIQMRGPBCQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26)
PubChem CID3408722
ChEMBLCHEMBL286252
IUPHAR44
BindingDB50133923
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Known GPCRs

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Total entries: 5
Page:  / 1 

GLASS IDNameUniProtGeneSpeciesLength
5539425-hydroxytryptamine receptor 1AP08908HTR1AHomo sapiens (Human)422
130941D(2) dopamine receptorP14416DRD2Homo sapiens (Human)443
553944D(2) dopamine receptorP61169Drd2Rattus norvegicus (Rat)444
130937D(3) dopamine receptorP35462DRD3Homo sapiens (Human)400
553943D(4) dopamine receptorP30729Drd4Rattus norvegicus (Rat)387

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